Sökning: "serum resistance"

Visar resultat 11 - 15 av 215 avhandlingar innehållade orden serum resistance.

  1. 11. The role of Moraxella catarrhalis outer membrane proteins in pathogenesis

    Författare :Taras Manolov; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cathepsin G; inflammation; serum resistance; C3; complement; Moraxella catarrhalis; antichymotrypsin; affinity chromatography; purification;

    Sammanfattning : Moraxella catarrhalis is an important respiratory pathogen. It is a common cause of otitis media in children, a usual infections agent in sinusitis and makes up to 10% of all exacerbations of chronic obstructive pulmonary disease (COPD). LÄS MER

  3. 12. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery

    Författare :Maria T. Lindgren; Helena Danielson; Jozsef Tözser; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; kinetics; biosensors; ADME; drug discovery; SPR; resistance; inhibition; copper; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. LÄS MER

  4. 13. Modulators of Vibrio cholerae predator interaction and virulence

    Författare :Barbro Lindmark; Sun Nyunt Wai; Kristian Riesbeck; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; Caenorhabditis elegans; PrtV; outer membrane vesicles; non-O1 non-O139; serum resistance; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Vibrio cholerae, the causal agent of cholera typically encodes two critical virulence factors: cholera toxin (CT), which is primarily responsible for the diarrhoeal purge, and toxin-co-regulated pilus (TCP), an essential colonisation factor. Nontoxigenic strains expressing TCP can efficiently acquire the CT gene through lysogenic conversion with CTXΦ, a filamentous phage that encodes CT and uses TCP as a receptor. LÄS MER

  5. 14. Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance

    Författare :Viveka Schaar; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Moraxella catarrhalis; epithelial cells; beta-lactamase; non-typeable Haemophilus influenzae; outer membrane vesicles; polymicrobial infections; UspA1;

    Sammanfattning : Outer membrane vesicles (OMV) have the size of nanoparticles and are released from the outer membrane of most Gram-negative bacteria. The OMV reflect the composition of the bacterial outer membrane, including lipids and virulence factors specific for the pathogen, and are involved in pathogenesis and bacterial survival. LÄS MER

  7. 15. Obesity-associated inflammation in adipose tissue

    Författare :Malin Alvehus; Tommy Olsson; Agneta Holmäng; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; inflammation; pro-inflammatory cytokines; serum; obesity; weight loss; menopause;

    Sammanfattning : Background: Excess body fat, particularly in the visceral depot, is linked to increased mortality and morbidity, including the development of diseases such as type 2 diabetes, cardiovascular disease, and cancer. Chronic low-grade inflammation in adipose tissue may be a key mediator of obesity-associated diseases. LÄS MER