Sökning: "serial passage"
Hittade 3 avhandlingar innehållade orden serial passage.
1. Dynamics of the Bacterial Genome : Rates and Mechanisms of Mutation
Sammanfattning : Bacterial chromosomes are highly dynamic, continuously changing with respect to gene content and size via a number of processes, including deletions that result in gene loss. How deletions form and at what rates has been the focus of this thesis. In paper II we investigated how chromosomal location affects chromosomal deletion rates in S. LÄS MER
2. Evolution of New Genes and Functions
Sammanfattning : To answer major evolutionary questions, we need a better understanding of the effects of mutations on specific functions and organism fitness. The aim of this thesis was to elucidate how new functions evolve and potential trade-offs with the original function. LÄS MER
3. Genetic analysis of human astrocytic gliomas : xenografts as a research tool
Sammanfattning : Cancer is a genetic disorder of somatic cells. An accumulation of genetic changes is believed to result in neoplastic transformation and malignant progression. In humans, astrocytic gliomas are the most common primary tumors of brain tissue. They are malignancy graded according to World Health Organization criteria. LÄS MER