Hittade 5 avhandlingar innehållade ordet semisynthesis.
Sammanfattning : Natural products have been shown to be an important source of novel compounds for the development of new drugs and pesticides. However, many biologically active natural products contain reactive functionalities that make them toxic. LÄS MER
2. Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells
Sammanfattning : Cancer stem cells are a subpopulation of cells that possess an increased tumorigenic potential. Such cells are connected to drug resistance, metastasis, and cancer recurrence. In 2009, the polyether ionophore salinomycin was shown to exhibit selective activity against cancer stem cells. LÄS MER
Sammanfattning : The modification of drugs into pro-drugs is an attractive concept allowing you to tweak the chemical and physical properties of a drug without changing the original structure of the active compound. In principle, any compound possessing a preferred biological activity can be transformed into a pro-drug. LÄS MER
4. Amino acid-catalyzed synthesis of amino acid derivatives : Application and semi-synthesis of Paclitaxel, Docetaxel and their derivatives
Sammanfattning : This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. LÄS MER
Sammanfattning : Natural products have until recently provided the only remedy for treatment of diseases. The development of modern chemistry in the last centuries has opened the door for tapping into the chemical diversity found in nature. Synthetic natural products, together with analogues, are an important piece in the puzzle towards curing many ailments. LÄS MER