Sökning: "selenoproteins"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet selenoproteins.

1. 1. Selenium Compounds in Milk. Studies of Selenoproteins, Selenium Enrichment and Oxidative Stability of Food

   Författare :Tien Hoac; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metabolism; Biokemi; Metabolism; Biochemistry; Naturvetenskap; Natural science; Copper; Zinc; Oxidative stability; Thioredoxin reductase; Glutathione peroxidase; Selenoproteins; Milk; Selenium supplementation; Technological sciences; Teknik;

   Sammanfattning : Selenium is an essential nutrient and in animals and humans it can either be specifically incorporated into proteins as selenocysteine or randomly as selenomethionine. It can also occur as low-molecular-weight compounds and the form of selenium in foods may also influence food quality. LÄS MER

3. 2. Selenoproteins in the Bovine Mammary Gland. Regulation of mRNA and Protein Expression

   Författare :Katharina Bruzelius; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Livsmedelsteknik; Food and drink technology; metabolism; Biokemi; Metabolism; Biochemistry; Naturvetenskap; milk; Natural science; cancer; prolactin; insulin; hydrocortisone; retinoic acid; MAC-T; northern blot; two-dimensional electrophoresis; bovine mammary gland; selenium; selenoprotein;

   Sammanfattning : Selenium is a micronutrient that is essential for many important life processes due to the action of the specific selenoproteins containing one or more of the 21st amino acid, selenocysteine. Twenty-five selenoprotein genes have been found in the human genome but the function of many of them is not yet known. LÄS MER

4. 3. Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein

   Författare :Karin Anestål; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Thioredoxin reductase; TrxR1; SecTRAPs; selenoproteins; apoptosis; caspase-2; glutathione reductase; cisplatin;

   Sammanfattning : The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) are selenoproteins containing a selenocysteine (Sec) residue within a carboxyl terminal -Gly -Cys -Sec -Gly -COOH motif. LÄS MER

5. 4. Selenocysteine in proteins : properties and biotechnological use

   Författare :Linda Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Selenocysteine; recombinant selenoprotein production; thioredoxin reductase; enzymology; protein labeling; mite allergy; mouse model;

   Sammanfattning : Selenocysteine (Sec), the 21st amino acid, exists in all kingdoms of life and has unique biochemical properties, such as high electrophilicity and low pKa. The highly increased reactivity of selenoenzymes compared to their sulfur-containing cysteine-dependent homologs is generally regarded as the evolutionary reason for having selenoproteins. LÄS MER

7. 5. Selenium cytotoxicity in cancer

   Författare :Marita Wallenberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Selenium is an essential trace element, present in the 21st amino acid selenocysteine, which is specifically incorporated into selenoproteins. Today, there are 25 identified selenoproteins in humans, whereof many comprises redox active functions to uphold the intracellular redox balance. LÄS MER