Sökning: "selective cell-lysis"

Hittade 5 avhandlingar innehållade orden selective cell-lysis.

  1. 1. Microfluidic bases sample preparation for blood stream infections

    Författare :Sahar Ardabili; Aman Russom; Mats Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sample-preparation; microfluidics; sepsis; size-based separation; selective cell-lysis; immune-based isolation; Biotechnology; Bioteknologi;

    Sammanfattning : Microfluidics promises to re-shape the current health-care system by transferring diagnostic tools from central laboratories to close vicinity of the patient (point-of-care). One of the most important operational steps in any diagnostic platform is sample preparation, which is the main subject in this thesis. LÄS MER

  3. 2. Microfluidic blood sample preparation for rapid sepsis diagnostics

    Författare :Jonas Hansson; Hjalmar Brismar; Aman Russom; Fredrik Nikolajeff; KTH; []
    Nyckelord :3D fluidic networks; bacteria isolation; inertial microfluidics; lab-on-chip; microfluidics; particle filtration; PDMS membrane; selective cell lysis. sepsis;

    Sammanfattning : Sepsis, commonly referred to as blood poisoning, is a serious medical condition characterized by a whole-body inflammatory state caused by microbial infection. Rapid treatment is crucial, however, traditional culture-based diagnostics usually takes 2-5 days. LÄS MER

  4. 3. Natural killer cells in cancer : studies on migration and cytotoxicity

    Författare :Erik Wennerberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. Despite these recent advances the clinical success has to date been modest in treatment of solid tumors, owing both to suboptimal directed migration of NK cells and the tumor cell’s resistance to NK cell-mediated lysis. LÄS MER

  5. 4. Virus mediated induction of antibody independent cytotoxicity (VDCC) and enhancement of antibody dependent cytotoxicity (ADCC) in human lymphocytes in vitro

    Författare :Abdul-Razzak Alsheikhly; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Addition in vitro of small amounts of paramyxoviruses (Mumps or Sendai) to lymphocytes from healthy human donors induces a strong and non-selective cytotoxicity against a variety of target cells (VDCC, virus dependent cellular cytotoxicity). VDCC-like reactions are believed to play a role in vivo in the defense against virus infection and/or the causation of the tissue lesions associated with virus disease. LÄS MER

  7. 5. Novel microfluidic based sample preparation methods for rapid separation and detection of viable bacteria from blood for sepsis diagnostics

    Författare :Sharath Narayana Iyengar; Aman Russom; Jonas Tegenfeldt; KTH; []
    Nyckelord :microfluidics; Bioteknologi; Biotechnology;

    Sammanfattning : Sepsis is a serious medical condition characterized by a whole-body inflammatory response caused by bloodstream infection. The final stage of sepsis can lead to septic shock, multiple organ failure, and death. In early sepsis, the concentration of bacteria in the bloodstream is typically low, making diagnosis challenging. LÄS MER