Sökning: "selectins."

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet selectins..

  1. 1. Modulation of adhesion molecules on leukocytes during clinical and experimental hemodialysis : endothelial cell interacions

    Författare :Pia Thylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adhesion; adhesion molecules; complement; endothelial cells; hemodialysis; integrins; interleukin; leukocytes; selectins.;

    Sammanfattning : In patients on hemodialysis the sequential steps required for adhesion molecule mediated adherence of leukocytes to endothelial cells are unphysiologically disrupted since cell activation with subsequent alterations in adhesion molecule phenotypes takes place in the extracorporeal circuit far away from the respective endothelial cell ligand. The aims of the present investigations were to study the changes in adhesion molecule phenotypes on inflammatory cells induced by clinical and experimental hemodialysis and the consequences with regard to the capacity of the cells to adhere to endothelial cells. LÄS MER

  3. 2. Synthetic analogs of sialyl Lewis x

    Författare :Ulf Ellervik; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stereoselective synthesis; regioselective synthesis; lactam analogs; lactone; Selectin; Sialyl Lewis x; SLex; Organic chemistry; Organisk kemi;

    Sammanfattning : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. LÄS MER

  4. 3. Carbohydrate dependent adhesion of leukocytes and the role of fucosyltransferase VII

    Författare :Per Bengtson; Carl G. Galunberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Galectins, E-and P-selectins are carbohydrate-binding proteins that are up regulated at inflammatory lesions. Selectins expressed ou the activated endothelium mediate transient binding to leukocyte ligands that require sequential action of α 2,3-sialyltransferases and a 1,3-fucosyltransferases. LÄS MER

  5. 4. ß2 integrin-induced signal transduction events in human neutrophils

    Författare :Fredrik Melander; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; integrins; signal transduction; Rho GTPases; kinases; c-Cbl; General pathology; patologisk anatomi; pathological anatomy; Patologi allmän ; neutrophils;

    Sammanfattning : Inflammation is a localized protective response in vascularized tissues and can be induced by microbial infection or cell and tissue injury. Polymorphonuclear neutrophils (PMN) are the most common white blood cells and are recognized as major cellular mediators of acute inflammation. LÄS MER

  7. 5. Herpesvirus-induced glycans: Selectin ligands and related structures on the surface of the infected cell

    Författare :Rickard Nordén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Glycobiology; Herpesvirus; Selectin ligand;

    Sammanfattning : Human herpesviruses are usually acquired early in life and are widely distributed in the population. A common feature of all human herpesviruses is that they persist in the host after the primary infection. LÄS MER