Sökning: "sedation oral"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden sedation oral.

  1. 1. On oral health in children and adults with myotonic dystrophy

    Författare :Monica Engvall; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myotonic dystrophy; dental caries; gingivitis; dental care; oral sugar clearance; behavior management problems;

    Sammanfattning : Background: Myotonic Dystrophy type 1 (DM1) is a hereditary neuromuscular multisystem disease with varying clinical expressions and severity. The prevalence worldwide is 5-20/100 000. It is characterized by progressive muscular waste and myotonia. Facial weakness is one of the earliest and most constant features. LÄS MER

  3. 2. Allopregnanolone effects in women : clinical studies in relation to the menstrual cycle, premenstrual dysphoric disorder and oral contraceptive use

    Författare :Erika Timby; Marie Bixo; Torbjörn Bäckström; Anna-Carin N Wihlbäck; C Neill Epperson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABAA receptor; menstrual cycle; premenstrual dysphoric disorder; saccadic eye velocity; oral contraceptives; hypothalamic amenorrhea;

    Sammanfattning : Background: Premenstrual dysphoric disorder (PMDD) affects 3–8% of women in fertile ages. Combined oral contraceptives (OCs) are widely used and some users experience adverse mood effects. The cyclicity of PMDD symptoms coincides with increased endogenous levels of allopregnanolone after ovulation. LÄS MER

  4. 3. Pharmacokinetics of the enantiomers of thalidomide

    Författare :Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER

  5. 4. Clonidine in paediatric anaesthesia : pharmacokinetic and pharmacodynamic aspects

    Författare :Henrik T G Bergendahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alpha-2 adreoceptor agonists; anaesthesia; analgesia; bioavailability; clonidine; confusion; dose response; epidural; haemodynamics; intubation tracheal; midazolam; neuropeptide Y; paediatric; pharmacokinetic; postoperative; postoperative vomiting; premedication; sedation; shivering; variability.;

    Sammanfattning : Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. LÄS MER

  7. 5. Clonidine in pediatric anesthesia : aspects on population pharmacokinetics, nasal administration and safety

    Författare :Peter Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Clonidine is widely use as premedication in pediatric patients and has many beneficial effects in the perioperative period. The introduction of population pharmacokinetics in the 1980s has proven useful when performing pharmacokinetic studies in children to circumvent previous limitations with traditional pharmacokinetics. LÄS MER