Sökning: "secretory lysosomes"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden secretory lysosomes.

  1. 1. Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells

    Författare :Hanna Rosén; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; haematopoietic cells; Medicin människa och djur ; Medicine human and vertebrates ; secretory lysosomes; protein targeting;

    Sammanfattning : The cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. LÄS MER

  3. 2. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    Författare :Ying Gao; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER

  4. 3. Intracellular Degradation of Insulin in Pancreatic Islets

    Författare :Monica Sandberg; L.A.Håkan Borg; Stellan Sandler; Arne Andersson; Albert Salehi; Uppsala universitet; []
    Nyckelord :Cell biology; Cellbiologi;

    Sammanfattning : There is a substantial intracellular degradation of insulin in pancreatic islets. This may be a physiological process, which, in correspondence with biosynthesis and secretion of insulin, would optimize the secretory granule content of the pancreatic β-cell. LÄS MER

  5. 4. Degranulation in macrophages and other leukocytes: regulation by calcium, phosphoinositide 3-kinase, and protein kinase C

    Författare :Claes Nauclér; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lysosomal secretion; neutrophil; Clinical biology; proton pump; Klinisk biologi; exocytosis; lysosomal pH;

    Sammanfattning : Macrophages mediate innate immunity through release of cytokines, eicosanoids, reactive oxygen species as well as through phagocytosis and secretion of lysosomal enzymes. Regulation of lysosomal secretion in macrophages differs in several respects from release of specialized granules in other leukocytes. LÄS MER

  7. 5. Characterisation of HMGB1 in inflammation

    Författare :Therese Östberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : High mobility group box chromosomal protein 1 (HMGB1) was discovered over three decades ago as a nuclear protein which is present in all mammalian nucleated cells. Subsequent studies have revealed additional properties of HMGB1 besides its originally described nuclear functions. LÄS MER