Sökning: "secretory granule"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden secretory granule.

  1. 1. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion

    Författare :Ying Gao; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; extracellular fluids; Hematologi; Medicin människa och djur ; Haematology; Medicine human and vertebrates ; neutrophil; granule; secretory lysosome; sorting; phagocytosis; degranulation.; mast cell; hematopoietic cell; inflammation; soluble TNF receptor;

    Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER

  3. 2. Sorting and processing of neutrophil granule proteins

    Författare :Elinor Bülow; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secretion; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; cell-specific retention; chimeric; lysosome-related organelles; secretory pathway; propeptide of MPO; azurophil granules;

    Sammanfattning : The neutrophil granulocytes have a critical role in innate immunity in particular through phagocytosis of microorganisms. Their cytoplasmic granule subsets store digestive enzymes and antibiotic proteins that are released during this event. LÄS MER

  4. 3. β-cell dysfunction in Huntington's disease

    Författare :Karl Bacos; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; secretion; Insulin; trafficking; R6 2 mouse; granule; exocytosis; neurodegeneration; huntingtin;

    Sammanfattning : Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. LÄS MER

  5. 4. Mass spectrometric analyses of proteoglycans - Novel tools for studying prohormones in insulin-producing cells

    Författare :Mahnaz Nikpour; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteoglycan; glycosaminoglycan; mass spectrometry; secretory granule; prohormones; CRISPR Cas9;

    Sammanfattning : Proteoglycans (PGs) are proteins that carry one or more negatively charged glycosaminoglycan (GAG) chains. Proteoglycans have been identified in essentially all multicellular organisms, and are implicated in a wide range of biological and pathological processes. LÄS MER

  7. 5. Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells

    Författare :Hanna Rosén; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; haematopoietic cells; Medicin människa och djur ; Medicine human and vertebrates ; secretory lysosomes; protein targeting;

    Sammanfattning : The cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. LÄS MER