Sökning: "secreting"

Visar resultat 1 - 5 av 245 avhandlingar innehållade ordet secreting.

1. 1. Cyclic AMP oscillations in insulin-secreting cells

   Författare :Jenny Sågetorp; Uppsala universitet; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER

3. 2. Cyclic AMP Oscillations in Insulin-Secreting Cells

   Författare :Jenny Sågetorp; Anders Tengholm; Erik Gylfe; Lena Stenson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi;

   Sammanfattning : Cyclic AMP is an intracellular messenger that regulates numerous processes in various types of cells. In pancreatic β-cells, cAMP potentiates the secretion of insulin by promoting Ca2+ signals and by amplifying Ca2+-triggered exocytosis. Whereas Ca2+ signals have been extensively characterized, little is known about the kinetics of cAMP signals. LÄS MER

4. 3. Regulation of Phospholipase C and Plasma Membrane Phosphatidylinositol 4,5-bisphosphate in Insulin-Secreting Cells

   Författare :Sophia Thore; Anders Tengholm; Erik Gylfe; Peter Jones; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; PLC; PIP2; insulin-secreting cell; Ca2 ; evanescent wave microscopy; phosphoinositide kinase; ATP ADP ratio; Cellbiologi; Cell biology; Cellbiologi;

   Sammanfattning : The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is an important signaling molecule as substrate for the phospholipase C (PLC)-catalyzed formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol, and by directly regulating e.g. ion-channels, the cytoskeleton and vesicle trafficking in various types of cells. LÄS MER

5. 4. Lipid Signalling Dynamics in Insulin-secreting β-cells

   Författare :Anne Wuttke; Anders Tengholm; Erik Gylfe; Louis Philipson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; β-cell; diacylglycerol; insulin secretion; oscillations; PtdIns 4 P; PtdIns 4; 5 P2; protein kinase C; P2Y receptor; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Certain membrane lipids are involved in intracellular signalling processes, among them phosphoinositides and diacylglycerol (DAG). They mediate a variety of functions, including the effects of nutrients and neurohormonal stimuli on insulin secretion from pancreatic β-cells. LÄS MER

7. 5. Exocytosis in insulin secreting cells - role of SNARE-proteins

   Författare :Jenny Vikman; Diabetes - öcellsexocytos; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

   Sammanfattning : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. LÄS MER