Sökning: "sclc"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet sclc.

  1. 1. Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma

    Författare :Matilda Thorén; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small cell lung carcinoma; arsenic trioxide; hypoxia; hypoxia-inducible factors; survival; proliferation; glycolysis; glutamine metabolism; MYC;

    Sammanfattning : Small cell lung carcinoma (SCLC) is a very aggressive solid tumor and is often widely metastasized by the time of diagnosis. Despite good response to the initial chemotherapy, SCLC cells often develop multidrug resistance to conventionally used chemotherapeutic drugs, which cause almost all SCLC tumors to relapse. LÄS MER

  3. 2. Investigation of small-cell lung cancer epidemiology in Sweden and analysis of clinical and tumor specific prognostic biomarkers

    Författare :Salomon Tendler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Small-cell lung cancer (SCLC) accounts for approximately 13% of all newly diagnosed lung cancer (LC) cases. This disease is correlated with heavy smoking. It is characterized by a rapid doubling time combined with a propensity to metastasize quickly and by neuroendocrine differentiation. LÄS MER

  4. 3. Influence of hypoxia on differentiation and proliferation of non-malignant and tumor cells

    Författare :Marica Vaapil; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoxia; breast cancer; EPOR; small cell lung carcinoma; differentiation; proliferation; metabolism;

    Sammanfattning : Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. LÄS MER

  5. 4. Development of a vaccine against strangles

    Författare :Margareta Flock; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Strangles is an acute upper respiratory tract disease in the horse, which is characterized by purulent pharyngitis and lymphadenitis. It is caused by Streptococcus equi subsp. equi. The severe suffering and economical losses due to Streptococcus equi infections makes it one of the most important bacterial diseases in horses. LÄS MER

  7. 5. Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling

    Författare :Katarzyna Zielinska-Chomej; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is, despite rapid progress in development of new targeted therapies, still mainly treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned conventional therapies often meet general obstacles such as normal cell toxicity and tumour cell resistance. LÄS MER