Sökning: "sarcoma"

Visar resultat 11 - 15 av 84 avhandlingar innehållade ordet sarcoma.

  1. 11. Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics

    Författare :Josefin Fernebro; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; oncology; Soft tissue sarcoma; tumor periphery; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; multiple primary tumors; onkologi; cancer;

    Sammanfattning : Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. LÄS MER

  3. 12. Synovial sarcoma : molecular, biological and clinical implications

    Författare :Maria Törnkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :synovial sarcoma; translocations; fusion genes; SS18-SSX; IGF-1R; cyclin D1; antisense oligodeoxynucleotides.;

    Sammanfattning : Synovial sarcoma is a rare but mostly aggressive soft tissue tumor that mainly affects children and young adults. The tumor usually occurs in the vicinity of large joints, and may be subdivided into a classical biphasic type, a monophasic type or a poorly differentiated type, depending on histomorphological appearance. LÄS MER

  4. 13. FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects

    Författare :Malin Lindén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ewing sarcoma; Epigenetics; FET fusion oncoproteins; Myxoid liposarcoma; Proteomics; SWI SNF BAF chromatin remodeling complex;

    Sammanfattning : The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, including myxoid liposarcoma and Ewing sarcoma. The FET oncoproteins are thought to function as aberrant transcription factors, however, the exact oncogenic mechanism remains to be elucidated. LÄS MER

  5. 14. Sarcoma ecosystems : spatial characterization and prognostic significance

    Författare :Yanhong Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies necessitate a deeper understanding of sarcoma biology and personalized treatment strategies. LÄS MER

  7. 15. Ewing sarcoma : treatment, prognosis and late effects

    Författare :Asle Charles Hesla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ewing sarcoma (ES) is a rare and aggressive childhood/adolescent malignancy which relies on a multidisciplinary treatment approach for cure. The overall survival rate for this young patient group has hardly improved over the last 30 years despite large multinational treatment trials. LÄS MER