Sökning: "sanchez"

Visar resultat 1 - 5 av 65 avhandlingar innehållade ordet sanchez.

  1. 1. Genetic factors influencing susceptibility to intracellular infections

    Författare :Fabio Sánchez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Genetic susceptibility; leprosy; leishmaniasis; HIV; quantitative trait locus; linkage analysis; multigenic; severity.;

    Sammanfattning : Genetics of susceptibility to infection is a complex trait in which many factors from the host, the parasite and the environment, interact to produce different clinical manifestations of disease. This thesis explores the relationship between the first infectious susceptibility gene ever cloned, SLC11A1 and the occurrence of intracellular infections (leprosy, leishmaniasis and HIV infection) in several populations of humans. LÄS MER

  3. 2. Customization of tamoxifen therapy : not only a dream

    Författare :Betzabe Chavez Sanchez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer (BC) is the most common form of cancer in western women. The grand majority of the afflicted women are eligible for endocrine treatment. Tamoxifen has been the golden standard treatment for more than three decades. Unfortunately, resistance towards this drug is a major concern in the clinic. LÄS MER

  4. 3. Inorganic and organic polymer-grafted nanoparticles : their nanocomposites and characterization

    Författare :Carmen Cobo Sanchez; Eva Malmström; Henrik Hillborg; Anna Barros Timmons; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Si-ATRP; ATRP; polyelectrolytes; rGO; aluminium oxide; silica; CNF; CNC; PCL; LDPE; EBA; nanocomposites; matrix-free; extrusion; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : Nanocomposites (NCs) have been widely studied in the past decades due to the promising properties that nanoparticles (NPs) offer to a polymer matrix, such as increased thermal stability and non-linear electrical resistivity. It has also been shown that the interphase between the two components is the key to achieving the desired improvements. LÄS MER

  5. 4. Engineering Saccharomyces cerevisiae for mixed-sugar fermentation

    Författare :Rosa Garcia Sanchez; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; metabolic engineering; evolutionary engineering; promoter; mixed-sugar utilization; galactose; arabinose; xylose; Saccharomyces cerevisiae; fermentation; ethanol; phosphoglucomutase;

    Sammanfattning : Efficient fermentation of all the monomeric sugars derived from lignocellulose is crucial to increase the economy of bioethanol production, since they can account for a considerable fraction of the fermentable sugars in the raw material. This thesis describes the engineering of Saccharomyces cerevisiae strains for improved xylose, galactose and/or arabinose utilization. LÄS MER

  7. 5. Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells

    Författare :Sara Padrell Sánchez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been or are being tested in clinical trials. LÄS MER