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Visar resultat 1 - 5 av 9 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Salt-inducible kinases in adipose tissue

    Författare :Johanna Sernevi Säll; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; salt-inducible kinase; SIK; SIK2; fettväv; fettceller; insulinsignalering; glukosupptag; fetma; insulinresistens; salt-inducible kinase; SIK; SIK2; adipose tissue; adipocytes; insulin signalling; glucose uptake; obesity; insulin resistance;

    Sammanfattning : Obesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly in the modern society. The underlying mechanisms are complex and involve both environmental and genetic factors. Adipose tissue is an important organ for maintaining whole body energy homeostasis. LÄS MER

  3. 2. Salt-inducible kinase 1 : a novel regulator within a cell sodium-sensing network

    Författare :Karin Stenström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Na ; K -ATPase; -adducin; Milan hypertensive and normotensive strain of rats; hypertension; angiotensin II; cardiac hypertrophy; myocyte enhancer factor-2 and nuclear factor of activated T-cells;

    Sammanfattning : Na+, K+-ATPase (NK) is expressed in all animal cells and plays a crucial role in cellular ion homeostasis. The NK activity is tightly regulated by specific signaling networks that must be well controlled in time and space (at the plasma membrane or in the intracellular compartments) to guarantee the specificity of the physiological response. LÄS MER

  4. 3. Relevance of the salt-inducible kinase network for the development of high blood pressure and cardiac hypertrophy

    Författare :Sergej Popov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypertension (high blood pressure) is a multifactorial condition that remains a big worldwide problem. 95% of all hypertensive people suffer from essential hypertension with unknown causes. This can cause different heart diseases such as cardiac hypertrophy (CH), a condition which can ultimately lead to heart failure. LÄS MER

  5. 4. LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2

    Författare :Emma Henriksson; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; signal transduction; protein phosphorylation; LKB1; SIK2; SIK3; cAMP;

    Sammanfattning : Adipose tissue does not only store and release energy in response to hormones, it is also known as an endocrine organ, secreting important factors and hormones that influence for example appetite and insulin sensitivity. The association of type 2 diabetes with obesity has been known for quite some time. LÄS MER

  7. 5. Cross-regulation between TGFβ/BMP Signalling and the metabolic LKB1 pathway

    Författare :Erna Raja; Aristidis Moustakas; Tomi Mäkelä; Uppsala University Faculty of Medicine Ludwig Institute for Cancer Research; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cell signalling; TGFbeta; BMP; LKB1; AMPK; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Cell signalling determines physiological responses to many cellular stimuli and environmental changes. The transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP) signalling pathways begin by binding of ligand to the heterodimeric receptor complex, followed by activation of Smads that translocate to the nucleus to regulate transcription of genes that further mediate cellular physiology. LÄS MER