Sökning: "sPLA2"

Visar resultat 6 - 9 av 9 avhandlingar innehållade ordet sPLA2.

  1. 6. Studies on the structure, function and expression of phospholipase A2

    Författare :Pontus Larsson Forsell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Phospholipase A2 (PLA2) enzymes are widely distributed and the enzymes possess different functions such as a role in digestion and inflammation. PLA2 catalyzes the hydrolysis of the sn-2 acylester bond of phospholipids, yielding a free fatty acid and a lysophospholipid. LÄS MER

  3. 7. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts

    Författare :Tülay Yucel-Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :prostaglandin E2; cyclooxygenase; phospholipase A2 interleukin-1; tumor necrosis factor [alpha]; epidermal growth factor; protein kinase C; tyrosine kinases; human gingival fibroblasts;

    Sammanfattning : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. LÄS MER

  4. 8. Antibody- and osteoclast-dependent mechanisms of chronic pain

    Författare :Alexandra Jurczak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain is a frequent condition that affects approximately 20% of worldwide population with a higher prevalence among women. Due to the lack of optimal treatment, chronic pain leads to decreased life quality as well as significant physical and psychological complications. LÄS MER

  5. 9. Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease

    Författare :Anna Cederholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Systemic lupus erythematosus; cardiovascular disease; atherosclerosis; atherothrombosis; antiphospholipid antibodies; Annexin A5;

    Sammanfattning : Systemic Lupus Erythematosus (SLE) is a clinical syndrome of autoimmune origin. It manifests in diverse clinical and serological patterns and is considered to represent a prototype multisystemic autoimmune disease. The etiopathigenesis of SLE remains incompletely understood. LÄS MER