Sökning: "ryanodine receptors"
Hittade 5 avhandlingar innehållade orden ryanodine receptors.
1. Oscillatory Ca2+ signaling in glucose-stimulated murine pancreatic β-cells : Modulation by amino acids, glucagon, caffeine and ryanodine
Sammanfattning : Oscillations in cytoplasmic Ca2+ concentration ([Ca2+]i) is the key signal in glucose-stimulated β-cells governing pulsatile insulin release. The glucose response of mouse β-cells is often manifested as slow oscillations and rapid transients of [Ca2+] i. LÄS MER
2. Dynamics of Ca2 handling in vascular smooth muscle
Sammanfattning : Intracellular Ca2+ is a key regulator of vascular contractility, and thereby of blood perfusion and pressure. Ca2+ signals are essential also for cell migration, proliferation and regulation of numerous enzymes. LÄS MER
3. Anti-epileptic and neuroprotective mechanisms by Topiramate and Levetiracetam evaluated in primary cultures
Sammanfattning : The aim of this thesis was to evaluate plausible intracellular mechanisms of action for antiepileptic drugs, Topiramate (TPM) and Levetiracetam (LEV), and to investigate if TPM possesses neuroprotective properties. The thesis is based on results from calcium imaging, immunohistochemical stainings, viability tests, and Western blot using primary cortical or hippocampal cultures, or hippocampal brain slices. LÄS MER
4. Roles of the transient receptor potential channels and the intracellular Ca2+ channels in Ca2+ signaling in the beta-cells
Sammanfattning : Previous studies from our group reported that pancreatic β-cells express ryanodine receptors (RyRs) that can mediate Ca2+-induced Ca2+ release (CICR). The full consequences of the activation of RyRs on Ca2+ signaling in these cells, however, remained unclear. LÄS MER
5. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function
Sammanfattning : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. LÄS MER