Sökning: "rui zheng"

Hittade 1 avhandling innehållade orden rui zheng.

1. 1. Metabolomics, body composition and fracture

   Författare :Rui Zheng; Karl Michaëlsson; Harri Sievänen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; LC-MS; sample quality; cohort; body composition; fracture; Medicinsk vetenskap; Medical Science; Bioinformatics; Bioinformatik; Epidemiologi; Epidemiology; Orthopaedics; Ortopedi; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : In this thesis, I evaluated the impact of pre-centrifugation sample management on the plasma metabolome, providing verification for the protocol used in a study where I applied metabolomics to better understand the role of body composition in fracture occurrence using a large population-based cohort.  In paper 1, I applied untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics analysis to plasma samples (n = 471) from healthy donors to predict and evaluate the effect of pre-centrifugation temperature and delay time on metabolomics data using a combination of random forest and generalized linear models. LÄS MER