Sökning: "rodent and human neural stem cells"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden rodent and human neural stem cells.
1. Isolation and characterization of adult neural stem cells
Sammanfattning : Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in severe functional impairment and in some cases a vegetative state where life is supported artificially. The brain and spinal cord, constituting the CNS, have been viewed for decades as having limited capacity of regeneration with no neurogenesis in the adult. LÄS MER
2. Epigenetic and bioelectronic tools to study neural stem cells in health and disease
Sammanfattning : Brain development is a highly controlled, complex, and dynamic process. The mechanisms of its control need to accommodate the constantly changing contexts which, overtime, support the emergence of new neural structures and functions. LÄS MER
3. Neural stem cell engraftment : functional interactions, brain repair and gap junctions
Sammanfattning : Neural stem cell (NSC) engraftment therapies show increasing promise as potential cures for several of the diseases of the central nervous system. Traditionally, functional improvements after NSC engraftment have been attributed to replacement of lost neurons and astrocytes, remyelination and support of adjacent cells at risk. LÄS MER
4. From stem cells to neurons : a BMPy ride
Sammanfattning : Pinpointing the mechanisms behind the formation of the vertebrate development has been an intriguing and challenging task for researchers for several decades. In the 1980s two independent groups managed to isolate cells from the inner cell mass of a mouse blastocyst and to culture and expand them in vitro, while maintaining their pluripotency. LÄS MER
5. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease
Sammanfattning : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. LÄS MER