Sökning: "robust design"

Visar resultat 16 - 20 av 673 avhandlingar innehållade orden robust design.

  1. 16. Practical Optimal Experimental Design in Drug Development and Drug Treatment using Nonlinear Mixed Effects Models

    Författare :Joakim Nyberg; Andrew C. Hooker; Mats O. Karlsson; Sergei Leonov; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; robust design; optimizing drug development; population models; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident. LÄS MER

  3. 17. Robust optimisation of structures : Evaluation and incorporation of variations in simulation based design

    Författare :David Aspenberg; Larsgunnar Nilsson; Kjell Simonsson; Niels Olhoff; Linköpings universitet; []
    Nyckelord :TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : This thesis concerns the robustness of structures considering various uncertainties. The overall objective is to evaluate and develop simulation based design methods in order to find solutions that are optimal both in the sense of handling typical load cases and minimising the variability of the response, i.e. robust optimal designs. LÄS MER

  4. 18. Gain-Scheduled Controller Design

    Författare :Adrian Ilka; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Guaranteed cost control; Gain-scheduled control; Bellman-Lyapunov function; Lyapunov theory of stability; Robust control; Input output constraints; LPV system;

    Sammanfattning : This thesis is devoted to controller synthesis, i.e. to finding a systematic procedure to determine the optimal (sub-optimal) controller parameters which guarantees the closed-loop stability and guaranteed cost for uncertain nonlinear systems with considering input/output constraints, all this without on-line optimization. LÄS MER

  5. 19. Effective Sampling Design for Groundwater Transport Models

    Författare :Rune Nordqvist; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Earth sciences; Sampling design; design robustness; D-optimality; groundwater models; parameter estimation; model discrimination; Geovetenskap; Earth sciences; Geovetenskap; Hydrology; hydrologi;

    Sammanfattning : Model reliability is important when groundwater models are used for evaluation of environmental impact and water resource management. Model attributes such as geohydrologic units and parameter values need to be quantified in order to obtain reliable results. LÄS MER

  7. 20. Robust inference of gene regulatory networks : System properties, variable selection, subnetworks, and design of experiments

    Författare :Torbjörn E. M. Nordling; Elling W Jacobsen; Rolf Findeisen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; network inference; reverse engineering; variable selection; model selection; feature selection; subset selection; system identification; system theory; network theory; subnetworks; design of experiments; perturbation experiments; gene regulatory networks; biological networks;

    Sammanfattning : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. LÄS MER