Sökning: "ro52"

Visar resultat 6 - 10 av 17 avhandlingar innehållade ordet ro52.

  1. 6. The TRIM21/Ro52 E3 ligase and its antibodies in autoimmune disease

    Författare :Aurélie Ambrosi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with the systemic autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) often have autoantibodies against Ro/SSA (composed of the TRIM21/Ro52 and Ro60 antigens) and La/SSB. The biological function of the TRIM21/Ro52 protein itself has remained unknown until its recent description as a tripartite-motif (TRIM) family member and an E3 ligase involved in ubiquitination. LÄS MER

  3. 7. Structure-function studies on TRIM21/Ro52, a protein involved in autoimmune diseases

    Författare :Janosch Hennig; Maria Sunnerhagen; Kylie J. Walters; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : Several members of the tripartite motif (TRIM) protein family are involvedin antiviral activity and immunity and have been linked to severaldiseases. TRIM21, the main object of this thesis, is involved in Sjögrensyndrome (SS) and systemic lupus erythematosus (SLE), where patientsoften have autoantibodies against different epitopes on TRIM21. LÄS MER

  4. 8. Cutaneous lupus erythematosus and immunoreactivity in patients with Ro/SSA autoantibodies

    Författare :Karin Popovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cutaneous lupus erythematosus; Ro SSA autoantibodies; incidence; prevalence; photosensitivity; autoimmunity; HMGBI; Ro52;

    Sammanfattning : Lupus crythematosus (LE) is a heterogenous autoimmune disorder with many different clinical presentations. Cutaneous lupus erythematosus (CLE) is subdivided into acute, subacute and chronic CLE. Population-based epidemiologic studies of CLE are lacking arid the pathogenesis is not fully understood. LÄS MER

  5. 9. Studies on molecular regulation of inflammation in cutaneous lupus erythematosus

    Författare :Vilija Oke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lupus erythematosus (LE) is an autoimmune disease with a wide range of clinical manifestations. This spectrum spans from limited cutaneous disease to life-threatening rheumatic disorder involving vital organs. Sun exposure is an evident exogenous trigger of both cutaneous (CLE) and systemic LE (SLE). LÄS MER

  7. 10. Autoantibodies in congenital heart block

    Författare :Robert Klauninger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neonatal lupus erythematosus (NLE) affects neonates of Ro/SSA and La/SSB positive women. NLE is associated with several clinical manifestations including skin rash, cytopenia and congenital heart block (CHB). CHB is the most severe manifestation which can develop into a lethal atrioventricular (AV) block. LÄS MER