Sökning: "ro52"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet ro52.

  1. 1. TRIM21/ Ro52 in B cell pathology

    Författare :Susanna Brauner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease affecting 0.2% of the population. Several B cell aberrances have been linked to pSS, such as autoantibody production, hypergammaglobulinemia and B cell associated genetic polymorphisms. In addition, pSS patients display a 16 fold increased risk to develop B cell lymphomas. LÄS MER

  3. 2. A study on the E3 ligase TRIM21/Ro52

    Författare :Alexander Espinosa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 autoantibodies is used as a diagnostic tool, the biological function of TRIM21/Ro52 is still unknown. LÄS MER

  4. 3. The role of Ro52 autoantibodies in congenital heart block

    Författare :Stina Salomonsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Autoantibodies; Ro52; congenital heart block CHB ; Sjögren s syndrome SS ; autoimmunity; inflammation; autoantigen; germinal center GC ;

    Sammanfattning : The presence of B cells producing autoantibodies is a common feature of many autoimmune conditions. The pathogenic role of the autoantibodies is often unclear, but they often serve as diagnostic markers and may be used as prognostic tools in some diseases. LÄS MER

  5. 4. Ro52 antibodies and susceptibility genes in congenital heart block

    Författare :Linn S Strandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Congenital heart block (CHB) develops in fetuses of Ro/SSA and La/SSB positive women. During pregnancy, the autoantibodies cross the placenta and affect the fetus in which a potentially lethal atrioventricular (AV) block may develop. LÄS MER

  7. 5. Molecular characterization of the Ro52 autoantigen and its disease related epitopes

    Författare :Lars Ottosson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ro52; Sjögren s syndrome; autoantibodies; congenital heart block; molecular characterization; TRIM; RBCC; Zn2 ;

    Sammanfattning : The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. It is still unclear why these proteins become targets for the immune system, and how this autoreactivity is triggered. LÄS MER