Sökning: "ribosome display"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden ribosome display.
1. Ribosome display for selection and evolution of affibody molecules
Sammanfattning : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. LÄS MER
2. Nanoscopic adventures : unraveling macromolecular complexes in infectious diseases via integrative structural biology
Sammanfattning : This thesis focuses on understanding the underlying molecular mechanisms of infectious diseases, which claim nearly 9 million lives annually. The research centers on critical analysis of pathogen mechanisms and drug resistance. I have mainly focused on two clades of pathogens: Enterococcus faecalis and microsporidia. E. LÄS MER
3. Rational and combinatorial genetic engineering approaches for improved recombinant protein production and purification
Sammanfattning : The bacterium Escherichia coli (E. coli) is in many situations an ideal host for production of recombinant proteins, since it generally provides a rapid and economical means to achieve sufficiently high product quantities. LÄS MER
4. Intracellular Flows and Fluctuations
Sammanfattning : Mathematical models are now gaining in importance for descriptions of biological processes. In this thesis, such models have been used to identify and analyze principles that govern bacterial protein synthesis under amino acid limitation. LÄS MER
5. Biomolecular simulations, from RNA to protein : thermodynamic and dynamic aspects
Sammanfattning : The process of transforming the information stored in the DNA of genes into functional RNA molecules and proteins via transcription and translation is the most fundamental process of all known life. Even though these processes involve large macromolecules and dynamics on long time scales they all ultimately rely on atomic level interactions between nucleic acids or amino acids. LÄS MER