Sökning: "ribonuclease"
Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet ribonuclease.
1. Poly(A)-Specific Ribonuclease (PARN)
Sammanfattning : Degradation of the mRNA 3'-end located poly(A) tail is an important step for mRNA decay in mammalian cells. Thus, to understand mRNA decay in detail, it is important to identify the catalytic activities involved in degrading poly(A). LÄS MER
2. Poly(A)-specific Ribonuclease (PARN) : Structural and Functional Studies of Poly(A) Recognition and Degradation
Sammanfattning : Regulation of mRNA degradation is a powerful way for the cell to regulate gene expression. A critical step in eukaryotic mRNA degradation is the removal of the poly(A) tail at the 3'-end of the mRNA. LÄS MER
3. Electrospray Ionization Mass Spectrometry for Determination of Noncovalent Interactions in Drug Discovery
Sammanfattning : Noncovalent interactions are involved in many biological processes in which biomolecules bind specifically and reversibly to a partner. Often, proteins do not have a biological activity without the presence of a partner, a ligand. LÄS MER
4. Methods for the Synthesis of PET Tracers and NMR Studies of Ribonuclease A
Sammanfattning : This thesis contains two parts.In the first part, general and versatile palladium-mediated 11C-C bond forming reactions for use in the production of radiotracers for Positron Emission Tomography (PET) were explored. LÄS MER
5. Allosteric Regulation of mRNA Metabolism : -Mechanisms of Cap-Dependent Regulation of Poly(A)-specific Ribonuclease (PARN)
Sammanfattning : Degradation of mRNA is a highly regulated step important for proper gene expression. Degradation of eukaryotic mRNA is initiated by shortening of the 3’ end located poly(A) tail. Poly(A)-specific ribonuclease (PARN) is an oligomeric enzyme that degrades the poly(A) tail with high processivity. LÄS MER