Sökning: "retroviral transduction"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden retroviral transduction.
1. Retroviral gene transfer to repopulating hematopoietic cells
Sammanfattning : Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. LÄS MER
2. Semliki forest virus-derived packaging system for production of retroviral vectors
Sammanfattning : Gene therapy is a treatment of disease by transfer of genetic material into somatic cells of an individual. Successful gene therapy depends on a delivery system which can efficiently transfer the gene into target cells and lead to high level expression of the gene. LÄS MER
3. Genetic modification of human natural killer cells and possible applications thereof
Sammanfattning : Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear cells (PBMCs), IL-2 is of great importance. LÄS MER
4. Leukaemic relapse after allogeneic haematopoietic stem cell transplantation and the use of the graft-versus-leukaemia effect
Sammanfattning : Survival after allogeneic haematopoietic stem cell transplantation (HSCT) has improved over the last decades due to improvements in immunosuppressive regimens and supportive care. Today the major risk of treatment failure is recurrent leukaemia, a risk which has stayed relatively constant over the years. LÄS MER
5. Experimental gene therapy with special reference to plasma cell tumors
Sammanfattning : Gene therapy may open new perspectives in the treatment of numerous hematopoietic and metabolic disorders. Particularly, hematopoietic cells are very attractive targets for retroviral mediated gene transfer. LÄS MER