Sökning: "retinol dehydrogenase"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden retinol dehydrogenase.

  1. 1. Short-chain retinol dehydrogenases/reductases : Involvement in retinoid metabolism and expression in embryonic and adult mouse

    Författare :Paulina Tuvendal; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; -; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : Retinoids are needed in the embryo to ensure proper development and in the adult forvision, maintenance of epithelia and sperm production. Retinol is oxidised within the cell generating retinal and, irreversibly, retinoic acid. LÄS MER

  3. 2. Regulation of morphogen signalling during neural patterning in the Xenopus embryo

    Författare :Hooi Min Tan Grahn; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suppressor-of-fused; Gli; β-Catenin; Neural; Xenopus; FGF; Signalling; HtrA1; RDH10; Retinol dehydrogenase; Retinoic acid; Spemann s organizer; Induction; Gradient;

    Sammanfattning : Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. LÄS MER

  4. 3. Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases

    Författare :Kristian Tryggvason; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Retinol; vitamin A; retinol dehydrogenase; reporter assay;

    Sammanfattning : Retinoids (vitamin A derivatives) are vital nutrients that regulate a variety of physiological processes, including embryonic development, postnatal growth, reproduction, cell differentiation as well as maintenance of the immune system and vision. Most of the physiological functions of retinoids are believed to be controlled by retinoic acid (RA) altered gene expression via two classes of nuclear hormone receptors, the RARs and RXRs. LÄS MER

  5. 4. The molecular biology of retinoid metabolism : identification of an 11-cis retinol dehydrogenase in the retinal pigment epithelium

    Författare :András Simon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :11-cis retinol; 11-cis retinol dehydrogenase; chromophore; 11-cis retinaldehyde; 9-cis retinol; 9-cis retinol dehydrogenase; retinal pigment epithelium; vitamin A; short-chain alcohol dehydrogenase;

    Sammanfattning : Vitamin A derivatives (retinoids) are essential molecules in the course of embryonic development, postnatal growth and adult physiology. The physiological functions of retinoids are thought to be mediated mainly by retinoic acid which regulates the expression of various genes, and 11-cis retinaldehyde, which is the common chromophore of visual pigments. LÄS MER

  7. 5. Retinol dehydrogenases in retinoid metabolism : studies on a 9-cis/11-cis-retinol dehydrogenase in adult and embryonic tissues

    Författare :Anna Romert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Retinoids (vitamin A derivatives) are necessary for normal embryonic development and in the adult, for vision, differentiation of various epithelia, reproduction and in the immune system. The physiological effects of retinoids are mediated by binding to the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). LÄS MER