Sökning: "repurposed drugs"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden repurposed drugs.

1. 1. Pharmaceutical And Immunollogical Challenge Of Fungal Pathogens

   Författare :Marios Stylianou; Constantin F. Urban; Christophe d' Enfert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mast cells; Candida albicans; yeast to hyphal form; antifungal drugs; repurposed drugs; HTS;

   Sammanfattning : Incidences of fungal infections are on the rise in immunosuppressed people. Predominant causative agents for these mycoses are species of the genus Candida, including Candida albicans, Candida glabrata and Candida dublieniensis. Despite a wide range of emerging pathogens, C. albicans remains the leading cause. LÄS MER

3. 2. Computational and chemical approaches to drug repurposing

   Författare :Xuexin Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two primary approaches: computational and chemical. LÄS MER

4. 3. Novel treatment strategies for multidrug-resistant tuberculosis

   Författare :Lina Davies Forsman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tuberculosis is the leading cause of death from a single infectious agent in the world, surpassing the annual death toll of both malaria and HIV combined. The rise in multidrug-resistant tuberculosis (MDR-TB) has further exacerbated the situation, as this form of TB is more difficult and time-consuming to treat, with dismal cure rates. LÄS MER

5. 4. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies

   Författare :Madiha Nazir; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
   Nyckelord :cancer treatment; drug repositioning; Phosphodiesterase 3A PDE3A ; apoptosis; combination screening;

   Sammanfattning : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. LÄS MER

7. 5. Translational studies of epithelial cancer

   Författare :Johanna Classon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tumors stemming from specialized epithelial cells cause the most common cancer types and are among the leading causes of death in the western world. Although great strides have been made in early cancer detection, defining prognostic factors, and improving survival with novel treatments, cancers such as colorectal cancer and prostate cancer are incurable in their advanced stages. LÄS MER