Sökning: "repressor activator protein 1"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden repressor activator protein 1.

  1. 1. Molecular mechanisms of the transcriptional co-activator mastermind-like 1

    Författare :Magnus L Hansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene regulation is a complex process that requires several types of proteins, including chromatin-modifying enzymes, transcription factors, co-activators and co-repressors. We have investigated the molecular mechanisms underlying the action of the co-activator protein MAML1, which was first identified as a transcriptional co-activator for Notch receptors. LÄS MER

  3. 2. Regulation of HIV-1 provirus transcription

    Författare :Mojgan H Naghavi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Key words- HIV-1; LTR; transcription; subtypes; phylogenetic analysis; NFkappaB; USF; MCEF; HMG-1 DSP1; Dorsal.;

    Sammanfattning : Transcription of the HIV-genome is regulated by the interaction of viral long terminal repeat (LTR) cis-acting sequences with a complex of viral regulatory proteins and cellular transcription factors. The complex interplay between the cellular-, and/or viral proteins and LTR of different subtypes may play a role in the control of HIV-1 latency versus activation. LÄS MER

  4. 3. Viral Control of SR Protein Activity

    Författare :Camilla Estmer Nilsson; Neus Visa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; ASF SF2; dephosphorylation; E4-ORF4; L1; MLTU; PP2A; splicing; SR proteins; vaccinia virus; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Viruses modulate biosynthetic machineries of the host cell for a rapid and efficient virus replication. One important way of modulating protein activity in eukaryotic cells is by reversible phosphorylation. In this thesis we have studied adenovirus and vaccinia virus, two DNA viruses with different replication stategies. LÄS MER

  5. 4. RAP1 at the Yeast Telomere

    Författare :Johan Wahlin; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytogenetik; DNA-binding; Saccharomyces; yeast; telomeric repeat; telomere; RAP1; repressor activator protein 1; Genetics; cytogenetics; Genetik;

    Sammanfattning : Telomeres are specialized complexes of DNA and proteins that cap and confer stability to the ends of eukaryotic chromosomes. The telomeric DNA of most eukaryotes is composed of tandemly arranged short repeats. Within the budding yeasts these repeats are diverged in length as well as in nucleotide composition. LÄS MER

  7. 5. Regulation of plasminogen activator inhibitor-1 : role of triglyceride-rich lipoproteins, fatty acids and fibrate compounds

    Författare :Lennart Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :plasminogen activator inhibitor-1; coronary heart disease; endothelial cells; very low density lipoprotein VLDL ; 4G 5G polymorphism; VLDL response element; fibrate compounds; VLDL receptor; stroke;

    Sammanfattning : Impaired fibrinolytic function secondary to elevated plasma plasminogen activator inhibitor-1 (PAI-1) activity is associated with atherothrombotic disease, in particular coronary heart disease. Both environmental and genetic factors contribute to determine plasma PAI-1 levels and PAI-1 production in vivo. LÄS MER