Sökning: "replisome"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet replisome.

  1. 1. Dynamic Organization of Molecular Machines in Bacteria

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Bhupender Singh; Uppsala universitet.; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular machines; bacteria; cell cycle; ribosome; replisome; divisome; spore; E. coli; H. pylori; Mycobacteria; NATURAL SCIENCES Biology Organism biology Microbiology; NATURVETENSKAP Biologi Organismbiologi Mikrobiologi; Mikrobiologi; Microbiology;

    Sammanfattning : Bacterial cells were once treated as membrane-enclosed bags of cytoplasm: a homogeneous, undifferentiated suspension in which polymers (proteins, nucleic acids, etc.) and small molecules diffused freely to interact with each other. LÄS MER

  2. 2. Functional and structural characterization of the human mitochondrial helicase

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Författare :Jenny Korhonen; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mtDNA; replication; replisome; TWINKLE; mtSSB; POL g ; adPEO.;

    Sammanfattning : Mitochondria are the energy producing organelles of the eukaryotic cell. The human mitochondrial DNA (mtDNA) is a double stranded circular molecule of about 16 kb, usually present at 1000-10 000 copies per cell. The genome encodes 13 polypeptides involved in respiration, two ribosomal RNA s and a set of 22 transfer RNA s. LÄS MER

  3. 3. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes

    Detta är en avhandling från Umeå : Umeå University

    Författare :Parham Pourbozorgi Langroudi; Umeå universitet.; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G4; genome integrity; Pfh1; Top1; helicase; topoisomerase; replication; transcription;

    Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER

  4. 4. Molecular insights into mitochondrial dna replication

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Laboratory Medicine

    Författare :Javier Miralles Fusté; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Mitochondria are organelles found in eukaryotic cells. These organelles produce most of the adenosine triphosphate that cells use as a source of energy. Mitochondria contain their own genomic material, a circular DNA genome (mtDNA) that encodes subunits of the respiratory chain complexes and RNA components needed for mitochondrial translation. LÄS MER

  5. 5. DNA precursor biosynthesis-allosteric regulation and medical applications

    Detta är en avhandling från Umeå : Medicinsk kemi och biofysik

    Författare :Reza Rofougaran; Umeå universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; DNA biosynthesis; ribonucleotide reductase; allosteric regulation; Trypanosoma brucei; adenosine kinase; nucleoside analogs; mitochondrial DNA; TWINKLE; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme for de novo dNTP biosynthesis. We have studied nucleotide-dependent oligomerization of the allosterically regulated mammalian RNR using a mass spectrometry–related technique called Gas-phase Electrophoretic Mobility Macromolecule Analysis (GEMMA). LÄS MER