Sökning: "replication fork stability"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden replication fork stability.

  1. 1. Replication Fork Stability in Mammalian Cells

    Författare :Ingegerd Elvers; Thomas Helleday; Jan H. J. Hoeijmakers; Stockholms universitet; []
    Nyckelord :replication fork progression; replication fork stability; re-priming; DNA damage signalling; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Maintaining replication fork integrity is vital to preserve genomic stability and avoid cancer. Physical DNA damage and altered nucleotide or protein pools represent replication obstacles, generating replicative stress. Numerous cellular responses have evolved to ensure faithful DNA replication despite such challenges. LÄS MER

  3. 2. Replication fork stability in mammalian cells

    Författare :Ingegerd Elvers; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 3. Molecular mechanisms of mitochondrial DNA replication

    Författare :Teresa Holmlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mitochondria; mtDNA; replication; helicase; TWINKLE; POLgamma; POLgammaB; mtSSB; adPEO;

    Sammanfattning : Mitochondria are the energy producing organelles of eukaryotic cells. The organelle has its own genome, the mitochondrial DNA (mtDNA) that encodes 13 subunits of the respiratory chain (RC) complexes, two rRNAs and 22 tRNAs. LÄS MER

  5. 4. The Smc5/6 complex : linking DNA replication with chromosome segregation

    Författare :Kristian Jeppsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In order to faithfully propagate the genetic material from one generation to the next, cells need to properly replicate and segregate their chromosomes. The three well-conserved eukaryotic Structural Maintenance of Chromosomes (SMC) protein complexes, cohesin, condensin and the Smc5/6 complex (Smc5/6) organize chromosomes to ensure that the daughter cells receive a full complement of chromosomes. LÄS MER

  7. 5. Interplay between DNA repair pathways at replication forks in mammalian cells

    Författare :Fredrik Johansson; Dag Jenssen; Klaus Erixon; Harry Vrieling; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Sammanfattning : Cellular DNA is continuously being damaged by various agents of both endogenous and exogenous origin including a wide range of chemical compounds, UV-light and ionizing radiation. In order to remove lesions from the DNA and maintain genomic stability, different repair processes have evolved. LÄS MER