Sökning: "renal uptake"

Visar resultat 16 - 20 av 50 avhandlingar innehållade orden renal uptake.

  1. 16. Proinsulin C-peptide : membrane interactions and intracellular signaling

    Författare :Zhihui Zhong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human renal tubular cell; intracellular signal transduction; ERK1 2; JNK; Na ; K -A TPase; G-protein coupled receptor.;

    Sammanfattning : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. LÄS MER

  3. 17. Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids

    Författare :Olga Kotova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Na ; K -ATPase; insulin; C-peptide; exercise; in vitro contraction; cardiotonic steroids; ouabain; marinobufagenin; ERK 1 2 MAP kinase; Src; p90 rsk; GSK3; signaling cascade; glycogen synthesis; human skeletal muscle cells; human renal tubular cells; rat skeletal muscle.;

    Sammanfattning : Insulin and proinsulin-connecting peptide (C-peptide) stimulate Na+,K+-ATPase activity. The molecular mechanism by which insulin and C-peptide regulate the Na-pump in differentiated primary human skeletal muscle cells (HSMCs) and primary human renal tubular cells (HRTCs) was determined. LÄS MER

  4. 18. Ca2+ fluxes and insulin action in cardiac and skeletal muscles

    Författare :Johanna T Lanner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity and type 2 diabetes are major and rapidly increasing health problems in society. They are associated with several life-threatening conditions, including heart and renal failure, and damage to the nervous system. An inability of cells to respond normally to insulin, insulin resistance, is a key feature in obesity and type 2 diabetes. LÄS MER

  5. 19. Vascular endothelial growth factor B-role in metabolism, lipotoxicity and disease

    Författare :Annika Mehlem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Vascular Endothelial Growth Factor B (VEGF-B) was previously shown to control lipid uptake from the bloodstream via the endothelium into tissue cells, and when ablating Vegfb, intra-tissue lipid accumulation was reduced. However, very little is known regarding the metabolic role of VEGF-B in physiologic, or pathophysiologic conditions. LÄS MER

  7. 20. Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor

    Författare :Jeanna Perman; Göteborgs universitet; []
    Nyckelord :very low density lipoprotein receptor; lipid accumulation;

    Sammanfattning : Lipid accumulation in non adipose tissue is associated with various cases of tissue dysfunction and tissue failure. Reduced availability of oxygen is known to cause intracellular lipid accumulation in cardiomyocytes as well as in hearts. LÄS MER