Sökning: "renal toxicity"

Visar resultat 21 - 25 av 36 avhandlingar innehållade orden renal toxicity.

  1. 21. Aciclovir-induced neuropsychiatric symptoms : a clinical pharmacology study

    Författare :Anders Helldén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aciclovir (ACV) and its prodrug valacyclovir (VACV) are used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus (VZV), and as prophylaxis against cytomegalovirus (CMV) infections in immunocompromised patients. Treatment with ACV has decreased the mortality in herpes simplex encephalitis (HSE) from about 70 % to less than 30 %, and has also reduced the morbidity. LÄS MER

  3. 22. The ADAPT scaffold as a tool for diagnostic imaging and targeted therapy

    Författare :Emma von Witting; Sophia Hober; Inger Sandlie; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein G; ABD; ADAPT; affinity proteins; antibody; protein engineering; targeted therapy; nuclear medicine; molecular imaging; HER2; radionuclide therapy; Bioteknologi; Biotechnology;

    Sammanfattning : Molecular recognition, or the specific interactions between a protein and its ligand, is central to biology and a key factor for many different clinical and technical applications. Despite antibodies being only one of many different affinity proteins, it has by far been the most successful. LÄS MER

  4. 23. Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies

    Författare :Anna-Karin Elf; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroendocrine tumour; peptide receptor radionuclide therapy; somatostatin receptor 2 expression; radiosensitization; radioembolization; diffusion weighted imaging;

    Sammanfattning : ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. LÄS MER

  5. 24. Studies on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A homeostasis

    Författare :Charlotte Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TCDD; dioxin; vitamin A; retinoic acid; lecithin:retinol acyltransferase; retinyl ester hydrolysis; retinol-binding protein; kidney; lymph; stellate cell; kinetics; model-based compartmental analysis;

    Sammanfattning : Vitamin A (retinoids) is needed for normal vision, growth, reproduction, cell differentiation, embryonic development, and immune function. Retinoids exert their functions in the same way as classical hormones, as transcription factors acting via nuclear receptors. LÄS MER

  7. 25. Glucose degradation products in peritoneal dialysis fluids

    Författare :Martin Erixon; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Medicine human and vertebrates ; 4-dideoxyglucosone-3-ene; 3; cytotoxicity; storage; temperature; Glucose degradation products biocompatibility; sterlization; Medicin människa och djur ; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Patients suffering from renal failure must remove extracellular water and waste products from their body in order to survive. One way of doing this is by treatment with peritoneal dialysis (PD). LÄS MER