Sökning: "renal toxicity"
Visar resultat 11 - 15 av 36 avhandlingar innehållade orden renal toxicity.
11. Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
Sammanfattning : Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. LÄS MER
12. Antiapoptotic effect of ouabain in renal cells exposed to toxic glucose levels
Sammanfattning : Diabetes mellitus is a group of metabolic diseases that causes enormous social and economic burden. The kidney is the filtration organ that produces urine and is the primary target of diabetic complications, a condition called diabetic nephropathy (DN). LÄS MER
13. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell
Sammanfattning : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. LÄS MER
14. On paediatric regional anaesthesia : the use of paravertebral blockade, aspects on plasma protein binding, and systemic toxicity of local anaesthetics
Sammanfattning : Paediatric regional anaesthesia has gained widespread popularity during recent years because of an excellent potential for intra- and postoperative pain relief and reduction of the surgically induced stress response. The aim of the present thesis was to adapt and develop the technique of paravertebral blockade (PVB) for the safe use in paediatric patients and also to investigate aspects on plasma protein binding and toxicity of local anaesthetic drugs which might be of importance in the special settings of paediatric anaesthesia. LÄS MER
15. Prospective and longitudinal human studies of lead and cadmium exposure and the kidney
Sammanfattning : Cadmium and lead accumulate in humans and can have toxic effects. Exposure to cadmium is well known to cause kidney damage. Cadmium binds to metallothioneins, proteins that play a role in cadmium transport. LÄS MER