Sökning: "relative biological effectiveness RBE"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden relative biological effectiveness RBE.

  1. 1. Radiation-induced apoptosis in human lymphocytes : studies on expression, function and effects of different radiation qualities

    Författare :Annelie Meijer; Fabrizio Palitti; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; clonogenic survival; growth factors; chromosomal aberrations CA ; low dose-rate LDR ; linear energy transfer LET ; relative biological effectiveness RBE ; radio sensitivity; ataxia telangiectasia A-T ; Physical Biology; fysikalisk biologi;

    Sammanfattning : We are constantly exposed to radiation. Radiation causes damage to our cells. By the removal of damaged and unwanted cells, apoptosis is considered to be one of the most indispensable defence processes for a multi-cellular organism. LÄS MER

  3. 2. Relative biological effectiveness in proton therapy: accounting for variability and uncertainties

    Författare :Jakob Ödén; Iuliana Toma-Dasu; Kjell Eriksson; Radhe Mohan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proton therapy; relative biological effectiveness; linear energy transfer; proton track-end optimisation; radiation-induced toxicity; Medical Radiation Physics; medicinsk strålningsfysik;

    Sammanfattning : Radiation therapy is widely used for treatments of malignant diseases. The search for the optimal radiation treatment approach for a specific case is a complex task, ultimately seeking to maximise the tumour control probability (TCP) while minimising the normal tissue complication probability (NTCP). LÄS MER

  4. 3. Averaged linear energy transfer and other beam quality descriptors inr elation to relative biological effectiveness

    Författare :Fredrik Kalholm; Niels Bassler; Iuliana Toma-Dasu; Emanuele Scifoni; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LET; RBE; LQ-model; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : In radiotherapy with protons, a constant relative biological effectiveness (RBE) of 1.1 is traditionally applied, i.e. protons are assumed to be 10\% more effective than photons in killing cells. LÄS MER

  5. 4. Radiobiological investigations of proton and light ion therapy

    Författare :Nina Tilly; Michael Scholz; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiobiology; Monte Carlo method; Radiotherapy; high-energy instrumentation; Protons; Light ions; RBE; LET; Radiobiological models; Radiobiologi; medicinsk strålningsfysik; Medical Radiation Physics;

    Sammanfattning : During the last decade, the interest in proton and light ion beam therapy has increased considerably and several new centres are planned around the world. These particles have a large advantage due to their sharp physical dose distributions as compared to conventional radiotherapy beams. LÄS MER

  7. 5. Comparative Treatment Planning in Radiotherapy and Clinical Impact of Proton Relative Biological Effectiveness

    Författare :Jonas Johansson; Bengt Glimelius; Anders Montelius; Tony Lomax; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Radiotherapy; Comparative studies; Breast cancer; hypopharyngeal cancer; rectal cancer; Proton RBE; Onkologi; Oncology; Onkologi;

    Sammanfattning : The development of new irradiation techniques is presently a very active field of research with increased availability of more sophisticated modalities such as intensity modulated photons (IMRT), protons and light ions. The primary aim of this work is to evaluate if the dose-distributions using IMRT and protons contribute to clinical advantages. LÄS MER