Sökning: "relapse clinical trials"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden relapse clinical trials.

1. 1. Treatment failure in pediatric acute myeloid leukemia: factors associated with frequency and outcome of resistant disease and relapse

   Författare :Lene Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Relapse; Resistant disease; Measurable residual disease;

   Sammanfattning : Although the prognosis for childhood acute myeloid leukemia (AML) has improved over the last decades to a survival of over 70%, still 30-40 % relapse and 5-10% experience resistant disease with poor prognosis. The aim of this thesis was to perform a detailed analysis of disease characteristics and treatment in children with relapsed and resistant AML to provide means to improve prognosis. LÄS MER

3. 2. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption

   Författare :Andrea deBejczy; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol dependence; mirtazapine; varenicline; org 25935; alcohol markers; phosphatidylethanol; randomized controlled clinical trials RCT ; treatment; glycine transporter inhibitor; nAChR;

   Sammanfattning : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. LÄS MER

4. 3. Measurable residual disease and clonal evolution in acute myeloid leukemia with focus on NPM1-mutations

   Författare :Louise Pettersson; Lund Patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AML; MRD; Measurable residual disease; NPM1; NPM1-mutation; NPM1 type A mutation; clonal evolution; clonal patterns; subclones; genetic evolution; qPCR; RQ-PCR; ddPCR; deep seq; deep sequencing; NGS; RT-qPCR; old; elderly; MFC; flow cytometry;

   Sammanfattning : Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with mutations in the NPM1 gene occurring in almost one third of all cases. The ability to detect residual leukemia below the resolution of conventional microscopy is crucial for evaluation of relapse risk after therapy. LÄS MER

5. 4. EM Estimation in Phase Type Models

   Författare :Marita Olsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phase type distributions; coxian distribution; EM algorithm; I-divergence; density estimation; right censoring; interval censoring; standard error estimation; asymptotic theory; jackknife; relapse clinical trials; survival data; hidden Markov chain; I-divergence;

   Sammanfattning : This thesis consists of four articles whose theme in common is the class of phase type distributions. In the first article an EM algorithm is presented to estimate the parameters of a phase type distribution of fixed order. Also, it is shown that the algorithm can be used to approximate other continuous distributions by phase type distributions. LÄS MER

7. 5. Orthodontic retention : studies of retention capacity, cost-effectiveness and long-term stability

   Författare :Gudrun Edman Tynelius; Malmö högskola; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Retention strategies, cost-effectiveness and long-term stability oftreatment outcome are essential aspects of orthodontic treatmentplanning.The overall aim of this thesis was to compare and evaluate threedifferent retention strategies, with special reference to short- andlong-term clinical stability and cost-effectiveness. LÄS MER