Sökning: "regulatory toxicology"

Visar resultat 21 - 25 av 32 avhandlingar innehållade orden regulatory toxicology.

  1. 21. The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function

    Författare :Ulrika Mårtensson; Drug Target Discovery; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; HIV SIV; TIG2 chemerin; transcriptional regulation; ligand activation; Co-receptor; GPCR; ChemR23 CMKLR1;

    Sammanfattning : In all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. LÄS MER

  3. 22. Glucagon-like peptide-1 and alcohol-mediated behaviors in rodents

    Författare :Daniel Vallöf; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; Dopamine; Gut-brain axis; Reward;

    Sammanfattning : Alcohol use disorder (AUD) is a serious cause of morbidity and mortality. However, due to the limited efficacy of existing pharmacotherapies, further investigations of potential neurochemical targets are required to define new pharmacological interventions. LÄS MER

  4. 23. Systemic and local regulation of experimental arthritis by IFN-α, dendritic cells and uridine

    Författare :Sudeep Chenna Narendra; Mattias Magnusson; Srinivas Uppugunduri; Alf Kastbom; Natacha Bessis; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In this thesis, we have studied the immunological processes of joint inflammation that may be targets for future treatment of patients with arthritis. We focus on the immune-modulating properties of interferon-α (IFN-α) and uridine in experimental arthritis. LÄS MER

  5. 24. Impact of epidemiologically identified mixtures of endocrine disrupting chemicals on metabolic programming

    Författare :Polina Lizunkova; Joëlle Rüegg; Elin Engdahl; Joachim Sturve; Carl-Gustaf Bornehag; Juliette Legler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocrine disrupting chemicals; Mixtures; Metabolism; Developmental Toxicology; Epigenetics; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : We are ubiquitously exposed to a plethora of endocrine-disrupting chemicals (EDCs), i.e. substances that alter the function(s) of the endocrine system. While ample evidence show individual EDC's influence on developmental processes resulting in adverse health outcomes, less is known about the effects of human-relevant EDC mixtures exposure. LÄS MER

  7. 25. Chlorinated Paraffins: improved understanding of their bioaccumulation and toxicity in Daphnia magna

    Författare :Mafalda Castro; Magnus Breitholtz; Anna Sobek; Elena Gorokhova; Lillemor Asplund; Martin Scheringer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chlorinated paraffins; POPs; bioaccumulation; toxicity; ecotoxicology; aquatic toxicology; daphnia magna; liposomes; passive dosing; hydrophobic; mixtures; Applied Environmental Science; tillämpad miljövetenskap;

    Sammanfattning : Chlorinated paraffins (CPs) are industrial chemicals, mainly used as flame retardants, plasticizers and metal cutting fluids. Their production has reached historically high levels in the last decade, with an annual production exceeding one million tonnes. LÄS MER