Sökning: "regulatory toxicology"

Visar resultat 11 - 15 av 32 avhandlingar innehållade orden regulatory toxicology.

  1. 11. Regulation of Polyamine Analogue-Induced Apoptosis in Human Breast Cancer Cells

    Författare :Martina Holst; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cancer; Animal physiology; Djurfysiologi; Pharmacological sciences; pharmacognosy; pharmacy; onkologi; Cytologi; cancerology; oncology; Cytochrome c; Cytology; Bcl-2; Mitochondrial respiration; Apoptosis; Human breast cancer cells; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Social medicine; Socialmedicin; samhällsmedicin; Mitochondria; Polyamine analogues;

    Sammanfattning : Apoptosis is a defined process for cells to commit suicide through a set of biochemical and morphological cell changes. Activated apoptotic signals converge on the mitochondria, leading to permeabilization of mitochondrial membranes and release of different apoptosis regulatory proteins into the cytosol. LÄS MER

  3. 12. Chemicals in consumer products : Towards a safe and sustainable use

    Författare :Linda Molander; Christina Rudén; Sven Ove Hansson; Mattias Öberg; KTH; []
    Nyckelord :consumer products; articles; hazardous chemicals; risk management; chemicals regulation; REACH; substitution; regulatory toxicology; European Union;

    Sammanfattning : Health and environmental risks associated with emissions of hazardous chemicals from articles, including everyday consumer products such as clothes and toys, have become widely acknowledged internationally, particularly in the EU. This thesis contributes to new understandings of how these risks are currently managed within the EU and recommends actions for ensuring a safe and sustainable use of chemicals in articles. LÄS MER

  4. 13. Asymmetric Information and The Production of Health

    Författare :Mattias Lundbäck; Nationalekonomiska institutionen; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; ekonomisk teori; ekonometri; Nationalekonomi; economic policy; economic theory; economic systems; Economics; econometrics; reimbursement; health care; moral hazard; quality; asymmetric information; ekonomiska system; ekonomisk politik; Hospital science and management; Sjukhusforskning; sjukhusförvaltning; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The common theme of this thesis is the analysis of asymmetric information when applied to the market for health care production. The thesis consists of six more or less independent papers and an introduction to the thesis were purpose and methodology are stated (part one). Part two is an investigation into the pricing of pharmaceuticals in Sweden. LÄS MER

  5. 14.

    Författare :Klas Bergenheim; Nationalekonomiska institutionen; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; ekonometri; Nationalekonomi; economic policy; economic systems; economic theory; econometrics; Economics; toxikologi; farmaci; Pharmaceutical R D; Patents; Pricing of Pharmaceuticals; Real Options; Pharmacological sciences; pharmacy; pharmacognosy; toxicology; farmakognosi; Farmakologi; ekonomisk teori; ekonomiska system; ekonomisk politik;

    Sammanfattning : The first paper, Pharmaceutical R&D: a real option approach, considers the process of pharmaceutical R&D analyzed with real option theory. This process is analyzed as an opportunity to research and develop a new pharmaceutical. Contrary to other models using real option analysis I use an option that takes time to exercise. LÄS MER

  7. 15. Transcription Factor AP-2 in Relation to Serotonergic Functions in the Central Nervous System

    Författare :Mattias Damberg; Elias Eriksson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CNS; serotonin; transcription factors; AP-2; personality; antidepressants; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Eukaryotic gene transcription plays a regulatory role in mammalian developmental processes. It has been shown that transcriptional control is an important mechanism for specification of neurotransmitter phenotypes. LÄS MER