Sökning: "regulatory sequence analysis"
Visar resultat 1 - 5 av 67 avhandlingar innehållade orden regulatory sequence analysis.
1. Genetic and Genomic Analysis of DNA Sequence Variation
Sammanfattning : The studies in this thesis describe the application of genotyping and allele specific expression analysis to genetic studies. The role of the gene NPC1 in Triglyceride metabolism was explored in mouse models and in humans on the population level in study I. LÄS MER
2. A genomic approach to smooth muscle differentiation and diversity
Sammanfattning : Smooth muscle cells (SMCs) are a broad class of contractile cells that are found in a number of organs systems, including the vasculature, the urogenital system, the bronchi and the gastrointestinal tract. The two main functions exerted by SMCs are to provide contractile force and to synthesize structural components of the extracellular matrix. LÄS MER
3. On diverse biophysical aspects of genetics : from the action of regulators to the characterization of transcripts
Sammanfattning : Genetics is among the most rewarding fields of biology for the theoretically inclined, offering both room and need for modeling approaches in the light of an abundance of experimental data of different kinds. Many aspects of the field are today understood in terms of physical and chemical models, joined by information theoretical descriptions. LÄS MER
4. Functional analysis of genetic risk markers
Sammanfattning : Regulatory variants are the main factors responsible for genetic predisposition to how e.g. humans react differently to the environment. LÄS MER
5. Gene regulatory evolution in flycatchers: statistical approaches for the analysis of allele-specific expression
Sammanfattning : Understanding the molecular mechanisms underlying evolutionary changes in gene expression is a major research topic in biology. While a powerful approach to study this is the analysis of allele-specific expression (ASE), most of previously published methods can only be applied to lab organisms. LÄS MER