Sökning: "regulatory mechanisms"

Visar resultat 11 - 15 av 739 avhandlingar innehållade orden regulatory mechanisms.

  1. 11. Regulatory mechanisms in olfactory system assembly and function

    Författare :Carolyn Marks; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The mammalian sense of smell relies on the detection of odorants by a large family of G protein coupled receptors, encoded by ~1300 different genes in mice (Buck and Axel, 1991; Zhang et al., 2007). These odorant receptors (ORs) are expressed in olfactory sensory neurons (OSNs) in the main olfactory epithelium (MOE). LÄS MER

  3. 12. Chromosome-wide gene regulatory mechanisms in Drosophila melanogaster

    Författare :Anna-Mia Johansson; Jan Larsson; Kristen M. Johansen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chromatin structure; Drosophila; POF; disage compensation; gene expression; MSL; heterochromatin; Genetics; Genetik; genetik; Genetics;

    Sammanfattning : In Drosophila there are two different chromosome-wide targeting systems, the dosage compensation system that equalizes the transcriptional output from X-linked genes between males and females, and the regulation of the 4th chromosome mediated by the POF protein.   The best studied of these two mechanisms is the dosage compensation system. LÄS MER

  4. 13. Mechanisms of cell diversification

    Författare :Christopher Winston Uhde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell identity and function is determined by the intrinsic wiring of the gene regulatory network that endows progenitors with the competence to respond appropriately to extrinsic cues in a spatiotemporally-dependent manner. One such class of cues, morphogens, instruct cells in their identity by virtue of a concentration gradient, but how this is interpreted at gene regulatory levels to result in sharp and robust boundaries of gene expression is poorly understood. LÄS MER

  5. 14. Unraveling the regulatory mechanisms of pupal diapause termination

    Författare :Philip Süess; Philipp Lehmann; Christian Wegener; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Diapause; diapause termination; prothoracicotropic hormone; ecdysone; thermal performance; Functional Zoomorphology; funktionell zoomorfologi;

    Sammanfattning : Diapause is an essential part of many insect’s life cycle and is a developmental halt induced by environmental cues in advance of deteriorating conditions. Insects typically enter diapause to avoid unfavorable environmental conditions like low temperatures, poor food quality and the absence of conspecifics. LÄS MER

  7. 15. Mitochondria in Alzheimer disease : regulatory mechanisms and cell death

    Författare :Louise Hedskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Synaptic loss is the major correlate for cognitive decline in Alzheimer disease (AD). Processes taking place in the synapses are highly energy demanding and needs strict regulation, which makes the mitochondria and ER crucial at these sites so as to supply energy and spatially regulate intracellular calcium signaling. LÄS MER