Sökning: "regulatory T cell"

Visar resultat 16 - 20 av 395 avhandlingar innehållade orden regulatory T cell.

  1. 16. To be or not to be, unraveling molecular mechanisms for lineage decisions in developing blood cells

    Författare :Robert Månsson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; common lymphoid precursor CLP ; early B-cell factor 1 EBF1 ; B-cell; Stemcell; hematopoiesis; extracellulära vätskor; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : All hematopoietic cells originate from hematopoietic stem cells (HSC) residing in the BM. The process of differentiation, through which HSCs generate progenitors and subsequently mature blood cells has been extensively studied but many of the regulatory mechanisms involved remains elusive. LÄS MER

  3. 17. T cell signatures and modulation by regulatory T cells

    Författare :Rubin Narayan Joshi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : CD4 T cells are crucial coordinators of protective immune responses against microbes and tumors. However, immune responses misdirected towards self-antigens are the hallmarks of autoimmune diseases. Regulatory T cells (Tregs) maintain peripheral immune tolerance, mainly by suppressing effector T cells. LÄS MER

  4. 18. From dopamine nerve fiber formation to astrocytes

    Författare :Franziska Marschinke; Ingrid Strömberg; Cecilia Lundberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; dopaminergic neurons; astroglia; Cell biology; Cellbiologi; Histology; Histologi; neurologi; Neurology;

    Sammanfattning : Parkinson’s disease (PD) is a progressive neurodegenerative disease and characterized by the loss of dopaminergic (DA) neurons in the substantia nigra in the midbrain. The causes of the disease are still unknown. LÄS MER

  5. 19. Towards Immunotherapy of Midgut Carcinoid Tumors

    Författare :Sofia Vikman; Thomas Tötterman; Valeria Giandomenico; Bengt Widegren; Uppsala universitet; []
    Nyckelord :Immunology; midgut carcinoid; gene expression; immunotherapy; tumor antigen; VMAT-1; T cell; HLA-A*0201-binding peptide; IFNγ; regulatory T cell; Immunologi;

    Sammanfattning : Classical midgut carcinoids belong to neuroendocrine tumors of the gastroenteropancreatic tract (GEP-NETs) and are associated with serotonin overproduction. The term midgut is derived from the tumors’ embryological site of origin: enterochromaffin cells in the lower jejunum, ileum, caecum and the ascending colon. LÄS MER

  7. 20. Immunological strategies for counteracting type 1 diabetes focusing on IL-35 producing regulatory immune cells

    Författare :Zhengkang Luo; Kailash Singh; Stellan Sandler; Per-Ola Carlsson; Martin Blixt; Lina Thorvaldson; Arnaud Zaldumbide; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Regulatory T cell; Regulatory B cell; Interleukin-35; Immunologi; Immunology; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

    Sammanfattning : Type 1 diabetes (T1D) is an autoimmune disease where pancreatic β-cells are attacked by immune cells. Regulatory T (Treg) cells play critical roles in suppressing immune responses and their involvement have been intensively studied in T1D. Low dose IL-2 has been proposed to selectively boost Treg cells in T1D, with only limited success. LÄS MER