Sökning: "reference sequence database"

Hittade 5 avhandlingar innehållade orden reference sequence database.

  1. 1. Metagenomic Characterization of the Gut Microbiome in Cohorts of Elderly

    Författare :Sukithar K Rajan; Dirk Repsilber; Carl Mårten Lindqvist; Robert Jan Brummer; Lars-Gustav Snipen; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gut microbiota; metagenomics; High-Throughput Nucleotide Sequencing; reference sequence database; methods validation; microbial function; host-microbe interaction;

    Sammanfattning : Human gut microbiota plays a vital role in maintaining host health. This thesis aims to investigate the gut microbial population and function using next generation sequencing (NGS) data from faecal samples. Paper I examines the influence of sequencing depth and analysis methods in microbiota profiling using NGS whole genome sequencing (WGS) data. LÄS MER

  3. 2. The role of RFX transcription factors in neurons and in the human brain

    Författare :Debora Sugiaman-Trapman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : RFX transcription factors (TFs) are conserved in animals, fungi and some amoebae, but not in algae, plants and protozoan species. The conservation is based on the protein sequence of the DNA binding domain (DBD). The RFX DBD recognizes and binds to a DNA sequence motif called the X-box. LÄS MER

  4. 3. Genomics and bioinformatics approaches to functional gene annotation

    Författare :Danielle Kemmer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Biomedical research has been undergoing a quasi-revolution with the dawn of the genomics era. The flood of sequence data from the various genome projects, the task of cataloging the entire coding portion of a genome instead of identifying and characterizing individual genes, as well as technical demands accompanying these developments have posed great challenges to the research community. LÄS MER

  5. 4. Antibody repertoires : Exploration of their role in allergic disease and facilitation of reliable analyses thereof

    Författare :Linnea Thörnqvist; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; allergen; allergic disease; antibody bioinformatics; antibody repertoire; B cells; epitope; immunogloblulin; immunogloblulin germline gene; IgE; specific immunotherapy; stereotyped antibody;

    Sammanfattning : Allergic disease affects millions of individuals worldwide and leads to both impaired life quality of the affected individuals and large economic costs for the society. Allergen-specific antibodies of IgE type act as one of the key players in the disease, by activating effector cells upon binding of its allergen. LÄS MER

  7. 5. Epidemiology and etiology of pancreatic cancer

    Författare :Jiaqi Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pancreatic cancer is one of the most devastating malignancies with an extremely high fatality, resulting that its mortality rate almost equals to incidence rate. Although primary prevention is of upmost importance, the underlying etiology of this cancer remains largely unknown. LÄS MER