Sökning: "redesign"

Visar resultat 1 - 5 av 120 avhandlingar innehållade ordet redesign.

1. 1. Redesign Foundations

   Författare :Anna Lidström; Kirsti Bræin; Högskolan i Borås; []
   Nyckelord :HUMANIORA; HUMANITIES; waste; surplus; redesign; remake; design; method; clothing; Textiles and Fashion Design ; Textil och mode konstnärlig ;

   Sammanfattning : In relation to waste hierarchies, activities such as redesign, reuse, and remanufacturing are often promoted because they can recover more resources than other activities. For example, studies have repeatedly shown that reuse and remanufacturing have more beneficial effects for the environment than recycling on the fibre level. LÄS MER

3. 2. Modulating Enzyme Functions by Semi-Rational Redesign and Chemical Modifications : A Study on Mu-class Glutathione Transferases

   Författare :Malena A Norrgård; Bengt Mannervik; Birgitta Tomkinson; Timothy Mantle; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein redesign; semi-rational redesign; saturation mutagenesis; iterative saturation mutagenesis; chemical modification; Cys; Cys-X scanning; enzyme evolution; promiscuous; substrate selectivity; enantioselectivity; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : Today, enzymes are extensively used for many industrial applications, this includes bulk and fine-chemical synthesis, pharmaceuticals and consumer products. Though Nature has perfected enzymes for many millions of years, they seldom reach industrial performance targets. LÄS MER

4. 3. Rational redesign of Candida antarctica lipase B

   Författare :Anders Magnusson; Karl Hult; Bernhard Hauer; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Candida antarctica lipase B; rational redesign; secondary alcohols; substrate-assisted catalysis; S-selective; entropy; aldolase; stereospecificity pocket; oxyanion hole.; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : This thesis describes the use of rational redesign to modify the properties of the enzyme Candida antarctica lipase B. Through carefully selected single-point mutations, we were able to introduce substrate-assisted catalysis and to alter the reaction specificity. LÄS MER

5. 4. Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

   Författare :Olof Modén; Bengt Mannervik; Mikael Widersten; Kenneth Tew; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; allelic variants; azathioprine; bioactivation; chimeric mutagenesis; directed evolution; DNA shuffling; enzyme engineering; glutathione transferase; GST; lysate screening; molecular docking; multiple alignment; multivariate analysis; polymorphism; principal component analysis; prodrug; prodrug activation; protein engineering; protein redesign; reduced amino acid alphabet; saturation mutagenesis; semi-rational enzyme engineering; site-directed mutagenesis; structure-activity relationship; structure-based redesign; Biokemi; Biochemistry;

   Sammanfattning : Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. LÄS MER

7. 5. Remake: Design Foundations

   Författare :Anna Lidström; Lars Hallnäs; Högskolan i Borås; []
   Nyckelord :HUMANIORA; HUMANITIES; waste; surplus; redesign; remake; design; method; clothing;

   Sammanfattning : leftovers, waste, and surplus generated by increasing production and consumption of material goods. Their problem is not new, and over the last decade the search for a solution has given rise to various theories about and technologies for resource recovery and waste management. LÄS MER