Sökning: "recombinant scFv antibodies"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden recombinant scFv antibodies.

  1. 1. Recombinant Antibodies – Tools for building proteomic platforms

    Författare :Anna Säll; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody development; recombinant scFv antibodies; phage display; affinity proteomics; mass spectrometry;

    Sammanfattning : This thesis, which is based on four original papers, covers different aspects of the evolvement and development of proteomic platforms and the construction of human synthetic antibody libraries for the isolation of antibody reagents has been very central. There is an accelerating need for technologies capable of providing proteomic analysis of high sensitivity with good accuracy and an overall broad coverage as well as for biomarker validation. LÄS MER

  3. 2. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis

    Författare :Linn Petersson; Institutionen för immunteknologi; []
    Nyckelord :antibody arrays; recombinant antibodies; scFv; miniaturization of arrays; immobilization of scFv; global proteome analysis; biomarker discovery;

    Sammanfattning : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. LÄS MER

  4. 3. Recombinant antibodies and tumor targeting

    Författare :Ali Sheikholvaezin; Torgny Stigbrand; Gregory P Adams; Umeå universitet; []
    Nyckelord :immunologi; Immunology;

    Sammanfattning : Different antibody derived constructs are rapidly advancing as putative tools for treatment of malignant diseases. Antibody engineering has added significant new technologies to modify size, affinities, solubility, stability and biodistribution properties for immunoconjugates. LÄS MER

  5. 4. The CD40 Receptor - Target,Tool and Technology

    Författare :Peter Ellmark; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; SPIRE; mammalian; library; cDNA; selection; receptor revision; phage display; scFv; human; CD40; antibodies;

    Sammanfattning : CD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. LÄS MER

  7. 5. Design of antibody microarrays for global profiling of membrane proteins and soluble proteins

    Författare :Linda Dexlin Mellby; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scFv; membrane proteins; proteomics; protein chip; recombinant antibodies; Antibody microarray; protein profiling; membrane proteomics;

    Sammanfattning : Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification. LÄS MER