Sökning: "recombinant human growth hormone rhGH"

Hittade 4 avhandlingar innehållade orden recombinant human growth hormone rhGH.

  1. 1. Growth hormone responsiveness in children : results from Swedish multicenter clinical trials of growth hormone treatment

    Författare :Elena Lundberg; Berit Kriström; Kerstin Albertsson-Wikland; Roland Pfäffle; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gain in height; puberty; IGHD; non-GHD; IGF-I; bioavailability;

    Sammanfattning : The general aims of the thesis were to study GH responsiveness by estimation of pharmacokinetics and bioavailability of injected recombinant human GH (rhGH), of growth response as gain in heightSDS during childhood and puberty, and IGF-I response as change in circulating IGF-ISDS and IGFBP3SDS. Methods Short children were recruited during 1988–1999 into two national randomized multicentre clinical trials on growth until adult height. LÄS MER

  3. 2. Growth Hormone and Anabolic Androgenic Steroids : Effects on Neurochemistry and Cognition

    Författare :Alfhild Grönbladh; Mathias Hallberg; Jörgen Isgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; anabolic androgenic steroids; nandrolone decanoate; insulin-like growth factor; GABAB; opioids; memory; water maze; autoradiography; central nervous system; rats; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Sammanfattning : Growth hormone (GH) stimulates growth and metabolism but also displays profound effects on the central nervous system (CNS). GH affects neurogenesis and neuroprotection, and has been shown to counteract drug-induced apoptosis in the brain. LÄS MER

  4. 3. Performance and Scale-up of Escherichia coli Fed-batch Processes- Oxygenation of the Human Growth Hormone Process

    Författare :Andreas Castan; KTH; []
    Nyckelord :E. coli; fed-batch; DO-control; oxygen transfer; cell lysis; DNA release; mixed acid fermentation; formate formation; oxygen enriched air supply; flow cytometry; recombinant human growth hormone rhGH ;

    Sammanfattning : .... LÄS MER

  5. 4. Metabolic effects and long-term safety of childhood growth hormone treatment

    Författare :Anders Tidblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall aim of this thesis was to investigate the metabolic effects and long-term safety of childhood growth hormone (GH) treatment. In order to achieve this aim, the different projects consist of a two-part clinical trial on metabolic features linked to GH physiology and GH treatment as well as two large population-based cohort studies with focus on the long-term cardiovascular and cancer risks in previously GH-treated patients. LÄS MER