Sökning: "recombinant autoantigens"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden recombinant autoantigens.

1. 1. Humoral immunity to recombinant human autoantigens in organ-specific autoimmune disease

   Författare :Alberto Falorni; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IDDM; Addison s disease; autoantibodies; recombinant autoantigens; radioimmunoassay; disease prediction; glutamic-acid decarboxylase; steroid-21-hydroxylase;

   Sammanfattning : Insulin-dependent diabetes mellitus (IDDM) and idiopathic Addison's disease are organ-specific autoimmune diseases characterized by the presence of circulating autoantibodies. The role of autoantibodies in the pathogenesis of these diseases is not fully understood, but their presence can be used as a marker for diagnosis and prediction. LÄS MER

3. 2. Identification of autoantigens in multiple sclerosis

   Författare :Mattias Bronge; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system in which cells from primarily the adaptive immune system infiltrate the brain and spinal cord, leading to inflammation and demyelination. Debuting primarily between 20-40 years of age and with a prevalence in Sweden of ~0. LÄS MER

4. 3. Immune responses to the Ro and La autoantigens

   Författare :Pia Tengnér; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Sjögren s syndrome; systemic lupus erythematosus; Ro SS-A; La SS-B;

   Sammanfattning : Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are rheumatic diseases characterized by autoantibody production directed to the Ro/SS-A and La/SS-B autoantigens. The Ro/SS-A is a complex of one of four small RNAs denoted hY RNAs, and three proteins; Ro 60kD, Ro 52kD and La. LÄS MER

5. 4. RNA-protein complexes as autoantigens : cell and molecular biology of Ro/SSA and disease associations of anti-Ro/SSA antibodies

   Författare :Nader Pourmand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ro SSA; Ro 52kD; Ro 60kD; p40phox; Ig classes; systemic lupus erythematosus; Sjögren s syndrome; autoantibodies; immunoblotting;

   Sammanfattning : Autoantibodies to the Ro/SSA and La/SSB antigens are present in sera from patients with Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). The Ro/SSA autoantigen consists of a 52kD and a 60kD protein, complexed with one of four small RNAs. The La protein can also associate with the complex. LÄS MER

7. 5. Autoantigenic properties of the U1-70K protein

   Författare :Elisabet Welin Henriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :U1-70K protein; ribonucleoproteins; autoantigens; autoantibodies; epitopemapping; connective tissue disease; species specificity; cross reactions; amino acidsequence; recombinant proteins; mutagenesis;

   Sammanfattning : Patients with the autoimmune diseases systemic lupus erythematosus and mixed connective tissue disease produce autoantibodies directed towards specific groups of cellular constituents in their own body. Two of the targeted antigens are denoted Sm and RNP, and consist of distinct collections of splicing associated RNA-protein complexes. LÄS MER