Sökning: "recognition sites"

Visar resultat 1 - 5 av 126 avhandlingar innehållade orden recognition sites.

  1. 1. Chiral recognition on cellulases : The active sites of the enzymes are involved

    Författare :Hongbin Henriksson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Two cellobiohydrolases (CBH I and CBH II) and endoglucanase I (EG I) fromTrichoderma reesei, and CBH 58 from Phanerochaete chrysosporium were immobilized onsilica as chiral stationary phases (CSPs) in HPLC for enantioseparation of a group ofpharmaceutical compounds. CBH I and CBH 58 wore excellent chiral selectors for β-adrenergic blocking agents, whereas CBH II displayed good enantioselectivity for someother compounds The CBHs share the common feature that their active sites are located intunnels. LÄS MER

  3. 2. Molecular Recognition Studies Based on Imprinting Technology

    Författare :Cong Yu; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; imprinting; molecular recognition; polymer; chiral separation; acrylamide; chromatography; functional monomer; cross-linking; hydrogen bonding; hydrophobic interactions; aqueous media; solvent; antibody; mimics; receptor; artificial enzyme; Bioteknik; Biotechnology; Biokemi; Metabolism; Biochemistry;

    Sammanfattning : In this thesis, I have focused on five main research areas: 1). A new type of imprinted polymer has been developed, namely the amide MIP. The amide functional monomers showed better hydrogen bonding capabilities in polar organic solvents and the resulting polymers exhibited good enantiomeric recognition properties in organic media. LÄS MER

  4. 3. Towards the Rational Design of Molecularly Imprinted Polymers

    Författare :Håkan S Andersson; Ann-Christin Koch-Schmidt; Ian A Nicholls; Klaus Mosbach; Richard F Venn; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Thermodynamics; Molecular Recognition; Polyvalency; Cooperativity; Electrostatic Interactions; Hydrophobic Effect; Chromatography; Frontal Analysis; HPLC; Spectroscopy; Molecularly Imprinted Polymer; Molecular Imprinting; Crown Ether; Template Polymerisation; Cyclodextrin; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik; molecular recognition; Biokemi;

    Sammanfattning : Molecular imprinting is a technique by which polymeric materials selective for a given target molecule can be created through a casting procedure. Functionalised monomers are added to a solution of molecular templates. LÄS MER

  5. 4. Towards simulating fully charged protein-DNA systems in water : Zif268-DNA as a test case

    Författare :Git Roxström; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physics; Molecular Dynamics simulation; Zif268; zinc fingers; GROMOS; linkers; recognition sites; Fysik; Physics; Fysik; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : In this thesis, we develop a computing strategy to simulate fully charged protein-DNA systems with a general force field (GROMOS87). The ions neutralizing the phosphates (P-ions) are submitted to global symmetry constraints. A model exhibiting ionic-atmosphere effects on mobile P-ions was implemented via very weak restraint forces. LÄS MER

  7. 5. Uncertainty, Worth, Identity : How Early Career Academics Navigate Evaluative Landscapes

    Författare :Jonatan Nästesjö; Utbildningsvetenskap; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Akademiska karriärer; Akademiskt arbete; Socialisation; Identitet; Värde; Värdering; Utvärdering; Uncertainty; Erkännande; Belöning; Projektifiering; Projektbaserade karriärer; Meningsskapande; Gränser; Gränsarbete; Moral; Utvärderingslandskap; Högre utbildning; Unga forskare; Statsvetenskap; Historia; Sverige; Academic Careers; Academic Work; Socialization; Identity; Worth; Valuation; Evaluation; Uncertainty; Recognition; Reward; Projectification; Project-Based Careers; Meaning-Making; Boundaries; Boundary work; Morality; Evaluative Landscapes; Higher Education; Early Career Academics; Political Science; History; Sweden;

    Sammanfattning : This dissertation explores the interplay between valuation and academic socialization, addressing the question: how do early career academics navigate evaluative landscapes? Having completed their doctoral education but yet to find stable employment, early career academics are generally viewed as the most vulnerable group of academic staff. Comparing how individuals within this group seek to demonstrate their worth in order to be recognized by others and advance in their careers, I try to make sense of their world. LÄS MER