Sökning: "receptor up-regulation"

Visar resultat 11 - 15 av 123 avhandlingar innehållade orden receptor up-regulation.

  1. 11. Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli

    Författare :Sandra Lücke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells have to sense and adapt to changes in their surrounding environment. Most of the cellular responses to environmental and developmental stimuli are mediated by PAS (Per-ARNT-Sim) proteins. A member of this family of proteins is the aryl hydrocarbon receptor (AhR), a ligand-activated bHLH transcription factor and E3 ubiquitin ligase. LÄS MER

  3. 12. Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms

    Författare :Sabine Uhles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin receptor; signal transduction; gene expression regulation; insulin; glucokinase; cfos; pancreatic beta cell; membrane microdomains; green fluorescent protein.;

    Sammanfattning : Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently discussed as the result of the activation of specific signal transduction pathways. LÄS MER

  4. 13. Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro

    Författare :Håkan Karlsson; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokine; adhesion molecule; endothelium; lymphocyte metabolism; interleukin 2 receptor; FK506; cyclosporin A; Mikrobiologi; bakteriologi; virologi; mykologi; Immunology; transplantation; serology; Microbiology; bacteriology; mycology; virology; Immunologi; serologi;

    Sammanfattning : In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. LÄS MER

  5. 14. Dysregulation of receptor induced apoptosis during human leishmaniasis : a possible mechanism of skin ulceration

    Författare :Liv Eidsmo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cutaneous leishmaniasis; visceral leishmaniasis; Death Receptors; Fas; FasL; Apoptosis;

    Sammanfattning : Leishmaniasis is endemic in 88 countries and 12 million people per year have been estimated to be at risk of infection. The causative agent, the protozoan Leishmania, is spread by sand-flies and infects macrophages in the mammalian host. Leishmaniasis in humans form a spectrum of clinical presentations. In cutaneous leishmaniasis (CL) caused by L. LÄS MER

  7. 15. Effects of Inflammatory Mediators on Pulmonary Airways

    Författare :Ofir Bachar; Klinisk och experimentell allergiforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electric ?eld stimulation; bradykinin; airway; tumor necrosis factor a; Respiratory system; nitric oxide; Andningsorganen; Toll-like receptor; prostaglandin E2; neurotrophin; allergy;

    Sammanfattning : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. LÄS MER