Sökning: "receptor trafficking"
Visar resultat 21 - 25 av 74 avhandlingar innehållade orden receptor trafficking.
21. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system
Sammanfattning : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. LÄS MER
22. The galanin type 2 receptor: molecular biological, histochemical and electrophysiological studies
Sammanfattning : In the present thesis, the aim was to probe the distribution and functions of galanin type 2 receptor (GalR2) in the rodent brain. In order to overcome the lack of a reliable antibody to localize GalR2 by immunohistochemistry, we generated a construct which expresses GalR2 tagged with enhanced GFP (EGFP). LÄS MER
23. Impairment of B cell trafficking and differentiation during HIV-1 infection
Sammanfattning : During the course of HIV-1 infection, several B cell dysfunctions occur as result of virus replication and indirect mechanisms of immunopathology. The B cells abnormalities include hypergammaglobulinemia, a decreased number of memory B cells, increased levels of activation markers on B cell surface and plasmacytosis. LÄS MER
24. Trafficking of Human Dendritic Cells and B cells in Helicobacter pylori-induced Gastritis
Sammanfattning : Infection with the bacterium Helicobacter pylori is widespread throughout the world, and is associated with development of gastric and duodenal ulcer disease as well as gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. The infection generally leads to a large infiltration of immune cells, among them dendrite cells (DC) and IgA-secreting cells. LÄS MER
25. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy
Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER