Sökning: "receptor for advanced glycation end products"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden receptor for advanced glycation end products.

  1. 6. Diabetes and peripheral arterial disease

    Författare :Jonas Malmstedt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Diabetes mellitus increases the risk for peripheral arterial disease (PAD) early in life and the disease is likely to progress to advanced stages. Mechanisms responsible for premature PAD in diabetes are partly unknown. LÄS MER

  3. 7. Preterm and term cervical ripening : studies on CRH, HMGB1, toll-like receptors, cytokines and matrix metalloproteinases

    Författare :Aurelija Dubicke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical fibroblasts; cervical ripening; cervix; chemokines; cytokines; CRH; HMGB1; interleukin; labor; preterm; preterm labor; matrix metalloproteinases; pregnancy; PPROM; Tolllike receptors;

    Sammanfattning : Objective: Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. Despite the existing treatment, the frequency of PTB has not changed in the past thirty years. Incomplete understanding of the biological and pathophysiological mechanisms underlying preterm delivery is the major obstacle to preventing PTB. LÄS MER

  4. 8. Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine

    Författare :Gail E Mullins; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HMGB1; endothelial cells; pro-inflammatory; cytokine; RAGE;

    Sammanfattning : High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as a late mediator of septic shock in mice. LÄS MER

  5. 9. Cardiovascular morbidity and metabolic signature in patients with rheumatoid arthritis

    Författare :Mitra Nadali; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular mortality; Rheumatoid arthritis; metabolic signature;

    Sammanfattning : Background and objectives: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with excess risk for cardiovascular morbidity and mortality. The treatment of RA by anti-inflammatory drugs has dramatically been improved over the resent decades. LÄS MER

  7. 10. Effect of the quinoline-3-carboxamide ABR-215757 during inflammation

    Författare :Sofia Helmersson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : ABR-215757 (5757) is a quinoline-3-carboxamide (Q-compound) currently in clinical development for systemic sclerosis. Q-compounds have shown efficacy in several different models of autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis. However, the mechanism of action is still poorly understood. LÄS MER