Sökning: "receptor degradation"

Visar resultat 6 - 10 av 190 avhandlingar innehållade orden receptor degradation.

1. 6. Regulation of PDGFRβ signaling 

   Författare :Piotr Wardęga; Johan Lennartsson; Edvard Smith; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PDGF; HD-PTP; Alix; Cbl; Ub; Fer; Y857; Y771; downregulation; degradation; ubiquitination; activation loop; Cell and molecular biology; Cell- och molekylärbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Platelet-derived growth factor (PDGF) isoforms, which bind to closely related a- and b-tyrosine kinase receptors, induce migration, proliferation, survival and differentiation of mesenchymal cells. They signal by the active receptor attracting Src homology 2 (SH2) domain containing proteins, which subsequently initiate a set of signaling pathways. LÄS MER

3. 7. Diversification of TGF-β Signaling in Homeostasis and Disease

   Författare :Michael Vanlandewijck; Aristidis Moustakas; Carl-Henrik Heldin; Steven Dooley; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; signaling; SIK; EMT; polarity; Notch; ALK5; p21; growth arrest; Smurf; Smad7; receptor; SNF1LK; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling pathway, which plays important roles during embryogenesis and in the adult organism, signals via a heterodimeric receptor complex consisting of two type II and two type I receptors. LÄS MER

4. 8. Novel Regulators of the TGF-β Signaling Pathway

   Författare :Marcin Kowanetz; Aristidis Moustakas; Carl-Henrik Heldin; Caroline Hill; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-β; Smad; Id; EMT; cell cycle; SNF1LK; ubiquitin; degradation; signal transduction; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : The transforming growth factor-β (TGF-β) superfamily consists of related multifunctional cytokines, which include TGF-βs, activins, and bone morphogenetic proteins (BMPs) and coordinate several biological responses in diverse cell types. The biological activity of TGF-β members is executed by transmembrane serine/threonine kinase receptors and intracellular Smad proteins. LÄS MER

5. 9. Regulation of TGF-β Signaling by Post-Translational Modifications

   Författare :Peter Lönn; Aristidis Moustakas; Carl-Henrik Heldin; Petra Knaus; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TGF-β; Smad; PARP-1; PARG; ALK5; SIK; signal transduction; transcription; post-translational modification; phosphorylation; ubiquitin; ADP-ribosylation; DNA-binding; receptor degradation; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. LÄS MER

7. 10. Poly(Lactide-co-Glycolide) in Controlled-Release Pharmaceuticals - Release Mechanisms

   Författare :Susanne Fredenberg; Avdelningen för kemiteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; PLGA; Poly lactide-co-glycolide ; Release mechanism; Diffusion; Controlled Release; Degradation; Protein;

   Sammanfattning : Controlled-release formulations reduce the frequency of injections and better maintain plasma concentrations within the therapeutic window. Poly(D,L-lactide-co-glycolide) (PLG) is currently the most frequently used biodegradable polymer for this application. LÄS MER