Sökning: "receptor degradation"

Visar resultat 11 - 15 av 190 avhandlingar innehållade orden receptor degradation.

  1. 11. Nuclear receptor corepressor N-CoR : role in transcriptional repression

    Författare :Kristina Loinder; Mats Söderström; Eckardt Treuter; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The human body consists of a multitude of cells of varying appearance and function. With a few exceptions they are genetically identical, and the key to their divergence lies in their different specific patterns of gene expression. LÄS MER

  3. 12. Exploring and exploiting plant biomass degradation by Bacteroidetes

    Författare :Cathleen Kmezik; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polysaccharide utilization locus; plant biomass degradation; carbohydrate esterases; multidomain enzymes; Bacteroidetes; PUL transfer; carbohydrate-active enzymes; xylan;

    Sammanfattning : Bacteroidetes bacteria have evolved to become excellent biomass degraders. They achieved this by applying carbohydrate-active enzymes (CAZymes) and organizing genes connected to the degradation of specific polysaccharides into discrete gene cassettes, so-called polysaccharide utilization loci (PULs). LÄS MER

  4. 13. Vitamin D and its receptor in parathyroid tumors

    Författare :Pamela Correa; Martin Bäckdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; hyperparathyroidism; loss of heterozygoisty; vitamin D; vitamin D receptor; polymorphism; hydroxylase; genetics; tumorigenesis; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Correa, P. 2002. Vitamin D and its receptor in parathyroid tumors. Acta Universitatis Upsaliensis. LÄS MER

  5. 14. Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer

    Författare :Åsa Kronblad; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; General pathology; breast cancer; hypoxia; cyclin D1; Cytology; oncology; estrogen receptor; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Sammanfattning : Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamoxifen therapy. However, resistance to tamoxifen is often observed and possible mechanisms may be loss or reduction of ER, dysfunctional ER- signaling and ligand independent activation of the receptor. LÄS MER

  7. 15. Development of new affinity proteins for neurodegenerative disorders

    Författare :Linnea C. Hjelm; John Löfblom; Stefan Ståhl; Hanna Lindberg; Ylva Ivarsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; sequestrins; amyloid beta; alpha-synuclein; phage display; affibodies; blood–brain barrier; Transferrin receptor; receptor-mediated transcytosis; recombinant spider silk; Biotechnology; Bioteknologi;

    Sammanfattning : Neurodegenerative disorders include a full spectrum of diagnoses, including dementias and other neuronal diseases, characterised by degradation of neurons in the brain occurring along with disease progression. Amongst the dementias, the most prevalent are Alzheimer’s (AD) and Parkinson’s disease (PD) that affect millions of people worldwide. LÄS MER